Armah, Francis A., Annan, Kofi, Mensah, Abraham Y., Amponsah, Isaac K., Tocher, Derek A. and Habtemariam, Solomon (2015) Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.). Fitoterapia, 105. pp. 37-42. ISSN 0367-326X (doi:10.1016/j.fitote.2015.06.001)

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Abstract

The stem- and root-bark of Erythrophleum ivorense (A Chev., family, Fabaceae) are routinely employed in the West African traditional medicine to treat inflammation and a variety of other disease conditions. Although the chemistry and pharmacology of cassaine-type diterpene alkaloids isolated from the stem-bark of the plant are fairly established, the root-bark has not yet been investigated. In the present study, the crude aqueous-alcohol extract of the root-bark was demonstrated to display a time- and dose (30–300 mg/kg p.o.)-dependent anti-inflammatory effect in chicks. Comprehensive chromatographic analysis coupled with spectroscopic and X-ray study further allowed the assignment of one of the major anti-inflammatory constituents as a novel cassaine-type diterpene, erythroivorensin. The other major constituents were known anti-inflammatory compounds: a triterpene, betulinic acid and a flavonoid, eriodictyol. The dose (10–100 mg/kg p.o.)-dependent anti-inflammatory effects of the three compounds were either comparable or more significant than the positive control, diclofenac.

Item Type:	Article
Uncontrolled Keywords:	erythrophleum ivorense, fabaceae, erythroivorensin, betulinic acid, eriodictyol, anti-inflammatory, novel diterpene
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	06 Apr 2018 16:07
URI:	http://gala.gre.ac.uk/id/eprint/13738

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