Scoutaris, Nikolaos, Snowden, Martin ORCID: https://orcid.org/0000-0002-1087-2692 and Douroumis, Dennis ORCID: https://orcid.org/0000-0002-3782-0091 (2015) Taste masked thin films printed by jet dispensing. International Journal of Pharmaceutics, 494 (2). pp. 619-622. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2015.05.018)

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Abstract

Taste masking of bitter active substances is an emerging area in the pharmaceutical industry especially for paediatric/geriatric medications. In this study we introduce the use of jet – dispensing as a taste masking technology by printing mucosal thin films of three model bitter substances, Cetirizine HCl, Diphenylhydramine HCl and Ibuprofen. The process was used to dispense aqueous drugs/polymer solutions at very high speed where eventually the drugs were embedded in the polymer matrix. The in vivo evaluation of jet – dispensed mucosal films showed excellent taste masking for drug loadings from 20 - 40%. Jet dispensing was proved to make uniform, accurate and reproducible thin films with excellent content uniformity.

Item Type:	Article
Uncontrolled Keywords:	jet dispensing, printing, taste masking, water insoluble drugs
Subjects:	R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	16 Apr 2020 13:26
URI:	http://gala.gre.ac.uk/id/eprint/13488

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