Nabavi, S.F., Nabavi, S.M., Latifi, A.M., Mirzaei, M., Habtemariam, Solomon and Moghaddam, A.H. (2012) Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain. Pharmaceutical Biology, 50 (11). pp. 1380-1383. ISSN 1388-0209 (Print), 1744-5116 (Online) (doi:10.3109/13880209.2012.675341)

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Abstract

CONTEXT:

Quercetin is a well known aglycone flavonoid that is widely found in different food sources.

OBJECTIVE:

In this study, the in vivo neuroprotective potential of quercetin against sodium fluoride-induced oxidative stress was evaluated.

MATERIALS AND METHODS:

Wistar rats were divided into five treatment groups and then subjected to daily intraperitoneally treatment with quercetin (at 10 and 20 mg/kg body weight), vitamin C (at 10 mg/kg), or vehicle. After a 1 week treatment period, all groups except saline treated (normal group), were intoxicated with sodium fluoride (NaF) for 1 week. Rat brains were then removed and homogenized for measurement of antioxidant markers including superoxide dismutase (SOD), reduced glutathione, catalase, and lipid peroxidation final products.

RESULTS:

The thiobarbituric acid reactive substances (TBARS) levels in the heart homogenate of sodium fluoride treated rats (42.04 ± 2.14 nmol MDA eq/g tissue) increased compared to the normal rats (35.99 ± 1.08 nmol MDA eq/g tissue). Animals which were pretreated with quercetin at 20 mg/kg for 1 week prior to sodium fluoride intoxication showed significant reduction in the TBARS level (36.13 ± 1.12 nmol MDA eq/g tissue). Also, pretreatment with quercetin (20 mg/kg) restored the SOD and catalase activities and modified the level of reduced glutathione compared with the control group (p > 0.05).

DISCUSSION AND CONCLUSION:

The present study revealed a potent neuroprotective potential of quercetin against NaF-induced toxicity.

Item Type:	Article
Additional Information:	[1] Copyright: © 2012 Informa Healthcare
Uncontrolled Keywords:	Antioxidant enzymes, flavonoid, neural tissues, reduced glutathione
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	17 Oct 2016 09:13
URI:	http://gala.gre.ac.uk/id/eprint/13450

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