Habtemariam, Solomon, Sureda, Antony, Moghaddam, Akbar Hajizadeh, Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad and Abolhasani, Fatemeh (2013) Protective role of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in rat’s heart. Letters in Drug Design and Discovery, 10 (3). pp. 277-282. ISSN 1570-1808 (Print), 1875-628X (Online) (doi:https://doi.org/10.2174/1570180811310030012)

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Abstract

The purpose of this study was to examine the potential cardioprotective role of gallic acid, a natural phenolic acid isolated from Peltiphyllum peltatum, against sodium fluoride-induced oxidative stress in rat’s heart. Oxidative stress and cardiotoxicity were induced by drinking water containing 600 ppm of sodium fluoride (NaF) for a week. For determination of cardioprotective role of gallic acid, 10 and 20 mg/kg doses were intraperitoneally administrated daily for a week prior to NaF intoxication. Thiobarbituric acid reactive substances (TBARS), antioxidant enzyme activities (i.e. superoxide dismutase and catalase) and the level of non-enzymatic antioxidant (reduced glutathione) were evaluated in the homogenates of rat’s cardiac tissues. Vitamin C (10 mg/kg) was used as standard antioxidant for comparison. Thiobarbituric acid reactive substance levels in heart homogenates of NaF intoxicated rats significantly increased (59.36 ± 2.19 nmol MDA eq/g tissue) when compared with control group (43.51 ± 1.47 nmol MDA eq/g tissue) (P<0.001). Administration of gallic acid at 20 mg/kg resulted in a significant decrease in TBARS levels (48.48 ± 1.81 nmol MDA eq/g tissue) (P>0.05 vs. normal). Antioxidant enzyme activities and glutathione levels were significantly reduced in NaF-treated animals (P<0.001 vs. normal). Gallic acid of Peltiphyllum peltatum at 20 mg/kg totally reversed (P>0.05 vs. control group) the oxidative stress induced by NaF as evidenced from the measured biochemical markers: superoxide dismutase (102.21 ± 1.29 U/g tissue) and catalase (39.29 ± 1.49 μmol/min/mg protein) activities and reduced glutathione (5.11 ± 0.09 μg/mg protein) levels. We concluded that gallic acid mitigated NaF induced oxidative stress in rat heart.

Item Type:	Article
Additional Information:	[1] Copyright © Bentham Science Publishers. All Rights Reserved.
Uncontrolled Keywords:	cardioprotective, gallic acid, peltiphyllum peltatum, homogenate, sodium fluoride
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	17 Oct 2016 09:13
URI:	http://gala.gre.ac.uk/id/eprint/13429

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