Tsala, David Emery, Amadou, Dawe and Habtemariam, Solomon (2013) Natural wound healing and bioactive natural products. Phytopharmacology, 4 (3). pp. 532-560. ISSN 2046-1194

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Abstract

A wound is a disruption of the normal anatomical structure and function of a tissue. Wounds cure in an orderly and timely repair process which is characterized by three dynamic and interactive phases: inflammation, proliferation and the remodeling. The present review was designed to elaborate the cellular and molecular targets for plant secondary metabolites that target the various aspects of wound repair process. The common mechanism of action of natural products established through in vitro and animal studies include direct action on skin cells regeneration, increase in connective tissue deposition, antioxidant activity, inflammatory cells activity and modulation of cytokine and growth factor production and/or function. All these demonstrated pharmacological effects could be exploited to overcome an acute or pathological wound healing conditions. The therapeutic potential of various chemical classes of natural products that act through one or multiple targets are discussed.

Item Type:	Article
Additional Information:	[1] Copyright: © 2013 Inforesights Publishing UK. [2] Phytopharmacology is an international peer-reviewed open-access journal (http://inforesights.com/phytopharmacology/)
Uncontrolled Keywords:	Natural products, secondary metabolites, wound healing, inflammation, proliferation, remodeling
Subjects:	Q Science > QK Botany
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	06 Dec 2016 14:13
URI:	http://gala.gre.ac.uk/id/eprint/13424

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