Dawe, Amadou, Pierre, Saotoing, Tsala, David Emery and Habtemariam, Solomon (2013) Phytochemical Constituents of Combretum Loefl. (Combretaceae). Pharmaceutical Crops, 4. pp. 38-59. ISSN 2210-2906 (doi:https://doi.org/10.2174/2210290601304010038)

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Abstract

Combretum is the largest and most widespread genus of Combretaceae. The genus comprises approximately 250 species distributed throughout the tropical regions mainly in Africa and Asia. With increasing chemical and pharmacological investigations, Combretum has shown its potential as a source of various secondary metabolites. Combretum extracts or isolates have shown in vitro bioactivitities such as antibacterial, antifungal, antihyperglycemic, cytotoxicity against various human tumor cell lines, anti-inflammatory, anti-snake, antimalarial and antioxidant effects. In vivo studies through various animal models have also shown promising results. However, chemical constituents and bioactivities of most species of this highly diversified genus have not been investigated. The molecular mechanism of bioactivities of Combretum isolates remains elusive. This review focuses on the chemistry of 261 compounds isolated and identified from 31 species of Combretum. The phytochemicals of interest are non-essential oil compounds belonging to the various structural groups such as terpenoids, flavonoids, phenanthrenes and stilbenoids.

Item Type:	Article
Additional Information:	[1] Copyright: © Dawe et al.; Licensee Bentham Open. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/- licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Uncontrolled Keywords:	Combretum, phytochemistry, pharmacology, terpenoids, polyphenolic compounds, antibacterial activity, antifungal activity
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	19 Oct 2016 09:01
URI:	http://gala.gre.ac.uk/id/eprint/13421

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