Pawar, Harshavardhan V., Boateng, Joshua S. ORCID: 0000-0002-6310-729X, Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:https://doi.org/10.1002/jps.23968)

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Abstract

Wafers combining weight ratios of Polyox with carrageenan (75/25) or sodium alginate (50/50) containing streptomycin and diclofenac were prepared to improve chronic wound healing. Gels were freeze‐dried using a lyophilisation cycle incorporating an annealing step. Wafers were characterised for morphology, mechanical and in vitro functional (swelling, adhesion, drug release in the presence of simulated wound fluid) characteristics. Both blank (BLK) and drug‐loaded (DL) wafers were soft, flexible, elegant in appearance and non‐brittle in nature. Annealing helped to improve porous nature of wafers but was affected by the addition of drugs. Mechanical characterisation demonstrated that the wafers were strong enough to withstand normal stresses but also flexible to prevent damage to newly formed skin tissue. Differences in swelling, adhesion and drug release characteristics could be attributed to differences in pore size and sodium sulphate formed because of the salt forms of the two drugs. BLK wafers showed relatively higher swelling and adhesion than DL wafers with the latter showing controlled release of streptomycin and diclofenac. The optimised dressing has the potential to reduce bacterial infection and can also help to reduce swelling and pain associated with injury due to the anti‐inflammatory action of diclofenac and help to achieve more rapid wound healing. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci

Item Type:	Article
Additional Information:	[1] Attached is the peer reviewed version of the following article: Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. doi:10.1002/jps.23968, which has been published in final form at http://dx.doi.org/10.1002/jps.23968.
Uncontrolled Keywords:	FTIR, X-ray diffractometry, adhesion, anti-infectives, anti-inflammatory, dressing, freeze-drying/lyophilisation, swelling, wafers, wound healing
Subjects:	R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	16 Apr 2020 13:41
URI:	http://gala.gre.ac.uk/id/eprint/12400

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