Habtemariam, Solomon and Varghese, George K. (2014) The antidiabetic therapeutic potential of dietary polyphenols. Current Pharmaceutical Biotechnology, 15 (4). pp. 391-400. ISSN 1389-2010 (Print), 1873-4316 (Online) (doi:https://doi.org/10.2174/1389201015666140617104643)

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Abstract

Type-2 diabetes (T2D) is a complex metabolic syndrome that is characterized by persistent hyperglycemia due to either lack of insulin secretion and/or insulin resistance. The prevalence of T2D along with its major risk factor, obesity, has been increasing with an epidemic proportion in recent years. To date, there is no drug of cure for diabetes and the existing therapeutic approaches have serious drawbacks including side effects and loss of efficacy during prolonged use. Dietary polyphenols are one group of natural products that have shown promise as potential antidiabetic agents. In this review, their molecular mechanisms of action including, antioxidant, anti-inflammatory, receptor agonist/antagonist effect and modulation of key signal transduction cascades, glucose transport, enzyme activity, receptor agonistic/antagonist effect, etc. in major insulin-sensitive cells are discussed.

Item Type:	Article
Additional Information:	[1] Published in Current Pharmaceutical Biotechnology, 15(4), 2014. Thematic Issue: “Dietary Polyphenols: Well beyond the Antioxidant Capacity.” Guest Editors: Seyed Mohammad Nabavi, Maria Daglia, Antoni Sureda.
Uncontrolled Keywords:	anti-inflammatory, antioxidant, diabetes, enzyme inhibition, fatty acids metabolism, glucose metabolism, polyphenols, receptor modulation
Subjects:	R Medicine > RA Public aspects of medicine
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science
Related URLs:	Publisher
Last Modified:	14 Oct 2016 09:29
URI:	http://gala.gre.ac.uk/id/eprint/12266

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