Mitchell, A.J., Beaumont, H., Ferguson, D., Yadegarfar, M. and Stubbs, B. (2014) Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis. Acta Psychiatrica Scandinavica, 130 (6). pp. 439-451. ISSN 0001-690X (Print), 1600-0447 (Online) (doi:10.1111/acps.12336)

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Abstract

Objective: To investigate whether people with subjective memory complaints (SMC) but no objective deficits are at increased risk of developing mild cognitive impairment (MCI) and dementia.

Method: Major electronic databases were searched till 03/2014, and a meta-analysis was conducted using inception cohort studies.

Results: Across 28 studies, there were 29 723 unique individuals (14 714 with SMC and 15 009 without SMC) (mean 71.6 years) followed on average for 4.8 years through to dementia. The annual conversion rate (ACR) of SMC to dementia was 2.33% (95% CI = 1.93%–2.78%) a relative risk (RR) of 2.07 (95% CI = 1.76–2.44) compared with those without SMC (n = 15 009). From 11 studies the ACR of developing MCI was 6.67% (95% CI = 4.70–8.95%). In long-term studies over 4 years, 14.1% (9.67–19.1%) of people with SMC developed dementia and 26.6% (95% CI = 5.3–39.7) went on to develop MCI. The ACR from SMC to dementia and MCI were comparable in community and non-community settings.

Conclusion: Older people with SMC but no objective complaints are twice as likely to develop dementia as individuals without SMC. Approximately 2.3% and 6.6% of older people with SMC will progress to dementia and MCI per year.

Item Type:	Article
Additional Information:	This is the peer reviewed version of the above cited article which has been published in final form at http://dx.doi.org/10.1111/acps.12336. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords:	dementia, mild cognitive impairment, subjective memory complaints
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	16 Nov 2016 11:01
URI:	http://gala.gre.ac.uk/id/eprint/12228

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