Vancampfort, Davy, Probst, Michel, De Hert, Marc, Soundy, Andrew, Stubbs, Brendon, Stroobants, Marc and De Herdt, Amber (2014) Neurobiological effects of physical exercise in schizophrenia: a systematic review. Disability and Rehabilitation, 36 (21). pp. 1749-1754. ISSN 0963-8288 (Print), 1464-5165 (Online) (doi:10.3109/09638288.2013.874505)

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Abstract

Purpose: The aim of the present systematic review was to provide a summary of neurobiological effects of physical exercise for people with schizophrenia. Methods: A systematic review was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Searches were conducted up to April 2013 across three databases: Medline, PsycINFO, and Embase. A methodological quality assessment using the Downs and Black Quality Index was carried out with all of the included studies. Results: Of the 654 initial data search results, two studies reported in 3 articles including 48 patients (six women) with schizophrenia, met the eligibility criteria. The methodological quality of each study was high. Data on hippocampal volume changes following physical exercise were conflicting while physical exercise-induced changes in other brain areas were absent. Increases in hippocampal volume following physical exercise were correlated with improvements in aerobic fitness and short-term memory. Conclusions: Future research is needed to investigate whether brain health in people with schizophrenia is activity-dependent. Additionally, research that considers the neurobiological mechanisms and associated functional outcomes of physical exercise in individuals with schizophrenia is required.

Item Type:	Article
Uncontrolled Keywords:	physical activity, schizophrenia, neurobiology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Related URLs:	Publisher
Last Modified:	18 Nov 2016 16:12
URI:	http://gala.gre.ac.uk/id/eprint/10873

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