Everett, Jeremy ORCID: 0000-0003-1550-4482 (2013) New approaches to the design of large screening files for lead discovery. In: Lifescience R&D Big Data Leaders Forum, 3-5 Dec 2013, Basel, Switzerland.

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Abstract

This talk will cover the following areas:
1. the advent of plate-based diversity subset screening as a new paradigm to significantly increase the efficiency of lead discovery.
2. the importance of molecular redundancy, in addition to molecular properties and diversity as a key driver of screening file design.
3. examples of the implementation of these concepts in a large pharmaceutical R&D organisation.

Item Type:	Conference or Conference Paper (Paper)
Additional Information:	[1] This lecture was presented at the Lifescience R&D Big Data Leaders Forum held from December 3-5, 2013 in Basle, Switzerland. It was given within Stream 1, Discovery & Translational Science Big Data Forum, in the Accelerating R&D Programmes via Big Data Session on 3rd December 2013.
Uncontrolled Keywords:	lead discovery, molecular redundancy, HTS, plate based diversity screening
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI) Faculty of Engineering & Science
Related URLs:	Organisation Organisation Organisation
Last Modified:	19 Nov 2024 14:08
URI:	http://gala.gre.ac.uk/id/eprint/10797

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