Maniruzzaman, Mohammed, Boateng, Joshua S. ORCID: 0000-0002-6310-729X , Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2012) A review of hot-melt extrusion: process technology to pharmaceutical products [Review article]. ISRN Pharmaceutics, 2012:436763. pp. 1-9. ISSN 2090-6145 (Print), 2090-6153 (Online) (doi:https://doi.org/10.5402/2012/436763)

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Abstract

Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.

Item Type:	Article
Additional Information:	[1] Citation: Mohammed Maniruzzaman, Joshua S. Boateng, Martin J. Snowden, and Dennis Douroumis, “A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products,” ISRN Pharmaceutics, vol. 2012, Article ID 436763, 9 pages, 2012. doi:10.5402/2012/436763. [2] Copyright © 2012 Mohammed Maniruzzaman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords:	Hot melt extrusion; Taste masking; Solubility increase; Process technology; Formulation
Subjects:	Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	16 Apr 2020 13:26
URI:	http://gala.gre.ac.uk/id/eprint/10641

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