Kianfar, Farnoosh, Antonijevic, Milan ORCID: 0000-0002-5847-7886 , Chowdhry, Babur and Boateng, Joshua ORCID: 0000-0002-6310-729X (2012) Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs. Colloids and Surfaces B: Biointerfaces, 103. pp. 99-106. ISSN 0927-7765 (doi:https://doi.org/10.1016/j.colsurfb.2012.10.006)

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Abstract

Lyophilized muco-adhesive wafers with optimum drug loading for potential buccal delivery have been developed. A freeze-annealing cycle was used to obtain optimized wafers from aqueous gels containing 2% κ-carrageenan (CAR 911), 4% pluronic acid (F127), 4.4% (w/w) polyethylene glycol with 1.8% (w/w) paracetamol or 0.8% (w/w) ibuprofen. Thermogravimetric analysis showed acceptable water content
between 0.9 and 1.5%. Differential scanning calorimetry and X-ray diffraction showed amorphous conversion for both drugs. Texture analysis showed ideal mechanical and mucoadhesion characteristics whilst both drugs remained stable over 6 months and drug dissolution at a salivary pH showed gradual release within 2 h. The results show the potential of CAR 911 and F127 based wafers for buccal mucosa
drug delivery.

Item Type:	Article
Uncontrolled Keywords:	Amorphous; Buccal drug delivery system; Carrageena; Dissolution characteristics; Lyophilized wafer; (Muco)-adhesion
Subjects:	R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	07 Dec 2016 16:54
URI:	http://gala.gre.ac.uk/id/eprint/10519

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