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The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease

The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease

Moyes, David L., Martin, Alex, Sawcer, Stephen, Temperton, Nigel ORCID: 0000-0002-7978-3815, Worthington, Jane, Griffiths, David J. and Venables, Patrick J. (2005) The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics, 86 (3). pp. 337-341. ISSN 0888-7543 (doi:10.1016/j.ygeno.2005.06.004)

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Abstract

The human endogenous retroviruses HERV-K113 and HERV-K115 are full-length proviruses but unusual in being found in only a proportion of the population. Here, we study the geographic distribution of these HERVs and their prevalence in autoimmune disease. The frequency of HERV-K113 and HERV-K115 in 174 individuals from Africa was 21.8 and 34.1%, respectively, compared to 4.16 and 1% in 96 people in the United Kingdom ( p < 0.001). Prevalence in Yemen (n = 56) was 8 and 7.14% and in Papua New Guinea (n = 54) 0% for both.
In the United Kingdom, HERV-K113 was found in 15.6% of 96 Sjo¨ gren’s syndrome patients ( p < 0.01) and 11.9% of 109 multiple sclerosis patients ( p < 0.05). No increase in prevalence in either disease was seen with HERV-K115. These data suggest that both viruses are recently integrated and/or under positive evolutionary selection pressure. HERV-K113 may be a genetic risk factor for some types of autoimmunity.

Item Type: Article
Uncontrolled Keywords: endogenous retrovirus, HERV, Sjogren’s syndrome, multiple sclerosis, autoimmune disease
Subjects: Q Science > QR Microbiology > QR355 Virology
R Medicine > RC Internal medicine
Faculty / Department / Research Group: Faculty of Engineering & Science > Medway School of Pharmacy
Related URLs:
Last Modified: 16 Jul 2012 11:18
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/8564

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