Poly(amido-amine)s as carriers for intracellular delivery of drugs and proteins
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Fenili, Fabio, Ferrari, Elena, Manfredi, Amedea, Cavalli, Roberta, Richardson, Simon C.W., Ranucci, Elisabetta and Ferruti, Paolo (2012) Poly(amido-amine)s as carriers for intracellular delivery of drugs and proteins. In: Nanomedicine and Drug Delivery. Advances in Nanoscience and Nanotechnology (v.1). Apple Academic Press Inc., Toronto, Canada & New Jersey, USA., pp. 51-64. ISBN 978-1-926895-17-8 (hardback), 978-1-46-656007-9 (e-book)
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Abstract
Polyamidoamines (PAAs) are synthetic polymers carrying amide- (a) and tert-amine (b) groups regularly arranged along the polymer chain according to the sequences
…a…a…b…b… or …a…a…b…. They are prepared by Michael polyaddition of primary or secondary amines to bisacrylamides (Scheme 1) (Danusso and Ferruti, 1970;
Ferruti, 1996; Ferruti et al., 1985).
The PAAs are endowed with a combination of properties that make them appealing for practical applications, particularly in the biotechnological field.
| Item Type: | Book Section |
|---|---|
| Additional Information: | [1] This item appears as chapter 5 in the book |
| Uncontrolled Keywords: | drug delivery, gene therapy, polymers, nanomedicine, cytotoxicity, poly(amido-amine), poly(ethyleneimine), polyamidoamines, poly-L-lysine, poor drug solubility |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| School / Department / Research Groups: | School of Science School of Science > Department of Life & Sports Science |
| Related URLs: | |
| Last Modified: | 16 Jul 2012 16:13 |
| URI: | http://gala.gre.ac.uk/id/eprint/8470 |
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