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Poly(amido-amine)s as carriers for intracellular delivery of drugs and proteins

Poly(amido-amine)s as carriers for intracellular delivery of drugs and proteins

Fenili, Fabio, Ferrari, Elena, Manfredi, Amedea, Cavalli, Roberta, Richardson, Simon, Ranucci, Elisabetta and Ferruti, Paolo (2012) Poly(amido-amine)s as carriers for intracellular delivery of drugs and proteins. In: Sebastian, Mathew, Ninan, Neetha and Haghi, A.K., (eds.) Nanomedicine and Drug Delivery. Advances in Nanoscience and Nanotechnology (v.1). Apple Academic Press Inc., Toronto, Canada & New Jersey, USA., pp. 51-64. ISBN 978-1-926895-17-8 (hardback), 978-1-46-656007-9 (e-book)

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Abstract

Polyamidoamines (PAAs) are synthetic polymers carrying amide- (a) and tert-amine (b) groups regularly arranged along the polymer chain according to the sequences …a…a…b…b… or …a…a…b…. They are prepared by Michael polyaddition of primary or secondary amines to bisacrylamides (Scheme 1) (Danusso and Ferruti, 1970; Ferruti, 1996; Ferruti et al., 1985). The PAAs are endowed with a combination of properties that make them appealing for practical applications, particularly in the biotechnological field.

Item Type: Book Section
Additional Information: [1] This item appears as chapter 5 in the book
Uncontrolled Keywords: drug delivery, gene therapy, polymers, nanomedicine, cytotoxicity, poly(amido-amine), poly(ethyleneimine), polyamidoamines, poly-L-lysine, poor drug solubility
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Related URLs:
Last Modified: 05 Dec 2016 10:40
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/8470

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