Factors involved in formulation of oily delivery system for proteins based on PEG-8 caprylic/capric glycerides and polyglyceryl-6 dioleate in a mixture of oleic acid with Chitosan
Assaf, Shereen M., Al-Jbour, Nawzat D., Eftaiha, Ala'a F., Elsayed, Amani M., Al-Remawi, Mayyas M., Qinna, Nidal A., Chowdhry, Babur, Leharne, Stephen and Badwan, Adnan A. (2011) Factors involved in formulation of oily delivery system for proteins based on PEG-8 caprylic/capric glycerides and polyglyceryl-6 dioleate in a mixture of oleic acid with Chitosan. Journal of Dispersion Science and Technology, 32 (5). pp. 623-633. ISSN 0193-2691 (Print), 1532-2351 (Online) (doi:10.1080/01932691003659775)Full text not available from this repository.
Systematic experimental work is required to improve knowledge related to the use of oily delivery systems. This work aimed to examine the influence of different molecular weights chitosan on formation and solubilization ability of w/o system of Labrasol, Plurol Oleique, water and oleic acid. Phase diagrams were constructed. Size measurements were performed for each surfactant in oleic acid. Interfacial tension of chitosan was measured between oleic acid and water at pH 1.5 and 6.25. Effect of chitosan on microemulsion size was studied. When used to deliver rh insulin to diabetic rats, the mixture showed reduction in blood glucose compared to control.
|Uncontrolled Keywords:||oily delivery systems, chitosan, labrasol, plurol, oleique, oleic acid|
|Subjects:||Q Science > Q Science (General)|
Q Science > QR Microbiology
|School / Department / Research Groups:||School of Science|
School of Science > Department of Life & Sports Science
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||22 Jan 2013 16:01|
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