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Polyunsaturated fatty acids and immune cell functions

Polyunsaturated fatty acids and immune cell functions

Pinto, Eva (2007) Polyunsaturated fatty acids and immune cell functions. PhD thesis, University of Greenwich.

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Abstract

In MS patients there was a significantly positive relationship between membrane AA and TGF-ß1 indicating that it is the individual long chain (LC) PUFA, i.e. AA that regulate the levels of TGF-ß1. Investigation of the effects of n-6 and n-3 PUFAs on normal healthy PBMC production of TGF-ß1 in vitro showed that PBMC in the presence of phytohaemaglutinin (PHA) supplemented with LA, dihyomo-?-linolenic (DGLA) and arachidonic acid (AA) significantly increase TGF-ß1 compared with non-supplemented PHA-stimulated PBMCs. In contrast, TGF-ß1 levels from PHA-stimulated PBMCs supplemented with a-linolenic (ALA), eicosapentaenoic (EPA) or docosahexaenoic acid (DHA) were significantly decreased suggesting that n-6 fatty acids (LA, DGLA and AA) increase in vitro TGF-ß1 production by PHA-stimulated PBMCs and, in contrast, n-3 fatty acids (ALA, EPA and DHA) decrease TGF-ß1 production.

GLA-rich borage oil supplementation resulted in significantly decreased ex vivo monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1a (MIP-1a) and interleukin-8 (IL-8) production from PHA-or LPS-stimulated PBMC compared with baseline. It also significantly decreased cell surface expression of CD36+, CD54+ and CD62L+ on monocytes. In contrast, there was no association between LA-rich corn oil and these adhesion molecules and chemokines suggesting that GLA and/or its metabolites are affecting the chemokines and adhesion molecules studied.

Overall, results of this study indicate that n-6 long chain PUFAs may have anti-inflammatory properties and might therefore be beneficial in multiple sclerosis, atherosclerosis and other inflammatory diseases.

Item Type: Thesis (PhD)
Additional Information: uk.bl.ethos.442074
Uncontrolled Keywords: polyunsaturated fatty acid, PUFA, triglyceride, immune system, anti-inflammatory properties, inflammatory disease treatment,
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 17 Oct 2016 09:11
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/6268

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