Application of thermal methods to the study of structural- and stereo-isomeric amino acids in the solid-state

Cherry, Anthony J., Chowdhry, Babur Z., Leharne, Stephen A. and Antonijevic, Milan D. (2010) Application of thermal methods to the study of structural- and stereo-isomeric amino acids in the solid-state. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1320-1321. ISSN 0022-3573 (print), 2042-7158 (online)

Abstract

Thermal Analysis (TA) techniques measure a specific property
of a sample as a function of temperature (or time), and
are used in the pharmaceutical industry to study the solid-state properties of APIs and drug excipients [1].
The use of only one type of TA technique is unlikely to
provide a complete, coherent analysis of a sample; thus, a
number of TA techniques must be simultaneously employed.
In the case of amino acids, their study using TA is somewhat
rare, with the prevalent themes in literature focusing on
spectroscopic techniques [2] or biological studies.
This study aims to demonstrate the useful information TA
can provide with reference to the solid-state properties of
amino acids, with structural- and stereo-isomeric properties
being a key theme throughout.

Actions (login required)