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Application of thermal methods to the study of structural- and stereo-isomeric amino acids in the solid-state

Application of thermal methods to the study of structural- and stereo-isomeric amino acids in the solid-state

Cherry, Anthony J., Chowdhry, Babur Z., Leharne, Stephen A. and Antonijevic, Milan D. (2010) Application of thermal methods to the study of structural- and stereo-isomeric amino acids in the solid-state. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1320-1321. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

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Abstract

Thermal Analysis (TA) techniques measure a specific property of a sample as a function of temperature (or time), and are used in the pharmaceutical industry to study the solid-state properties of APIs and drug excipients [1]. The use of only one type of TA technique is unlikely to provide a complete, coherent analysis of a sample; thus, a number of TA techniques must be simultaneously employed. In the case of amino acids, their study using TA is somewhat rare, with the prevalent themes in literature focusing on spectroscopic techniques [2] or biological studies. This study aims to demonstrate the useful information TA can provide with reference to the solid-state properties of amino acids, with structural- and stereo-isomeric properties being a key theme throughout.

Item Type: Article
Additional Information: [1] Abstract published in Journal of Pharmacy and Pharmacology, Volume 62, Issue 10, October 2010 - Special Issue: UK-PharmSci 2010 - The Science of Medicines. Abstracts from the UK conference, 1-3 September 2010.
Uncontrolled Keywords: thermogravimetry, thermal analysis, amino acid, structural isomerism, stereo isomerism
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 05 Dec 2016 12:23
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4841

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