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1,4-Benzodiazipine-2-ones in medicinal chemistry

1,4-Benzodiazipine-2-ones in medicinal chemistry

Spencer, John, Rathnam, Rajendra P. and Chowdhry, Babur Z. (2010) 1,4-Benzodiazipine-2-ones in medicinal chemistry. Future Medicinal Chemistry, 2 (9). pp. 1441-1449. ISSN 1756-8919 (doi:10.4155/fmc.10.226)

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Abstract

1,4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to ‘classical’ CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.

Item Type: Article
Uncontrolled Keywords: G-protein coupled receptor antagonists, enzyme inhibitors, anticancer agents, palladacycle complexes, synthesis
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 08 Dec 2016 12:34
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4567

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