Investigation of the interaction between poloxamer 407 and poly (ethylene glycol) 600
Kianfar, F., Chowdhry, B.Z., Boateng, J.S. and Antonijevic, M.D. (2010) Investigation of the interaction between poloxamer 407 and poly (ethylene glycol) 600. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1341-1342. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)Full text not available from this repository.
The aim of this study was to evaluate the interactions between poly (ethylene glycol) (PEG) 600 and poloxamer 407 prior to their use in a pharmaceutical formulation.
Chemical interactions between various ingredients alter the stability of pharmaceutical product . Investigating the interaction between starting materials is a pre-requisite to develop a stable high quality pharmaceutical formulation. Changes in melting point  directly influence the stability of a product. One of the fundamental changes that might modify the melting point of a compound and consequently alter the stability of the system is the interaction between excipient(s) and API(s). The formation of a mixture following the interaction between component compounds, influences the characteristics of the system which therefore need to be determined.
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