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An absolute structure template for a unique voltage-gated sodium channel binding site

An absolute structure template for a unique voltage-gated sodium channel binding site

Palmer, Rex A., Potter, Brian S., Leach, Michael J., Jenkins, Terence C. and Chowdhry, Babur Z. (2010) An absolute structure template for a unique voltage-gated sodium channel binding site. MedChemComm, 1 (1). pp. 45-49. ISSN 2040-2503 (Print), 2040-2511 (Online) (doi:10.1039/C0MD00043D)

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Abstract

The X-ray crystallographic structures of the mesylate salts of a novel voltage-gated sodium channelbinding ligand R-(-)-BW202W92 and its much less active S-(+)-enantiomer (BW203W92) have beendetermined to establish their absolute configurations. Each enantiomer exists as two distinct atropisomeric forms in the solid state and the crystal structures for each enantiomer are stabilized by quite distinct patterns of intermolecular hydrogen bonding. Such structural differences will influence the pharmacological properties of the enantiomers and hence dictate their contrasting receptor binding properties.

Item Type: Article
Additional Information: [1] First published online: 9th June 2010. [2] First published in print: July 1 2010. [3] Published as: Med. Chem. Commun., 2010, 1, (1), 45-49. [4] Electronic supplementary information (ESI) available: Experimental details and Supplementary tables. CCDC reference numbers 299482, 299483. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c0md00043d. [4] MedChemComm is the official journal of the European Federation for Medicinal Chemistry (EFMC).
Uncontrolled Keywords: voltage-gated sodium channels, BW202W92, BW203W92, X-ray crystallographic structures
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Related URLs:
Last Modified: 05 Dec 2016 12:48
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4301

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