Diet and gene expression: delta-5 and delta-6-desaturases in healthy Chinese and European subjects
Xiang, Mingyan, Rahman, Mohammed.A., Ai, Hua, Li, Xian and Harbige, Laurence S. (2006) Diet and gene expression: delta-5 and delta-6-desaturases in healthy Chinese and European subjects. Annals of Nutrition and Metabolism, 50 (6). pp. 492-498. ISSN 0250-6807Full text not available from this repository.
Aim: To compare the composition of fatty acids (FAs) in diet, and the expression of delta-6 desaturase (D6D) and delta-5 desaturase (D5D) genes in peripheral blood mononuclear cells (PBMCs) between Chinese and Europeans. Methods: Three-day dietary records from 20 subjects from Beijing, China (n = 10) and Kent, UK (n = 10) were analysed. Expression of PBMC D6D and D5D genes of the subjects was determined using RT-PCR. Results: The dietary intake of Chinese subjects contained less saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs), but more essential fatty acids (EFAs) than that of Europeans. Levels of expression of PBMC D6D and D5D genes of Chinese subjects were significantly lower than those of Europeans. A significant positive correlation was found between dietary intake of total SFAs and total MUFAs and expression of PBMC D6D and D5D genes, but a significant negative correlation between dietary intake of linoleic acid (LA) and α-linolenic acid (LNA) and the expression of PBMC D6D and D5D genes. Conclusion: Intake of high SFAs and MUFAs appears to increase expression of PBMC D6D and D5D genes, whilst high EFAs intake appears to decrease expression of PBMC D6D and D5D genes. A follow-up study of the expression of D6D and D5D genes in Chinese who live in European countries with high SFA and MUFA diets would be of interest. Copyright © 2006 S. Karger AG, Basel.
|Uncontrolled Keywords:||fatty acids, carboxlyic acids, diet, genes|
|Subjects:||R Medicine > RM Therapeutics. Pharmacology|
Q Science > QP Physiology
|School / Department / Research Groups:||School of Science > Department of Life & Sports Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
School of Science
|Last Modified:||31 Mar 2011 18:21|
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