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Modelling of dosator operation for improved manufacturing performance

Modelling of dosator operation for improved manufacturing performance

Angulo Pinzon, O.A., Berry, R.J., Bradley, M.S and Antonijevic, M.D. (2009) Modelling of dosator operation for improved manufacturing performance. In: 2009 AAPS Annual Meeting and Exposition, 8-12 Nov 2009, Los Angeles, USA.

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Abstract

Purpose: To develop an improved mathematical model for the prediction of dose accuracy of Dosators - based upon the geometry of the machine in conjunction with measured flow properties of the powder.

Methods: A mathematical model has been created, based on a analytical method of differential slices - incorporating measured flow properties. The key flow properties of interest in this investigation were: flow function, effective angle of wall friction, wall adhesion, bulk density, stress ratio K and permeability. To simulate the real process and (very importantly) validate the model, a Dosator test-rig has been used to measure the forces acting on the Dosator during the filling stage, the force required to eject the dose and the dose weight.

Results: Preliminary results were obtained from the Dosator test-rig. Figure 1 [Omitted] shows the dose weight for different depths to the bottom of the powder bed at the end of the stroke and different levels of pre-compaction of the powder bed. A strong influence over dose weight arising from the proximity between the Dosator and the bottom of the powder bed at the end of the stroke and the conditions of the powder bed has been established.

Conclusions: The model will provide a useful tool to predict dosing accuracy and, thus, optimise the future design of Dosator based equipment technology – based on measured bulk properties of the powder to be handled. Another important factor (with a significant influence) on Dosator processes, is the condition of the powder bed and the clearance between the Dosator and the bottom of the powder bed.

Item Type: Conference or Conference Paper (Poster)
Additional Information: [1] This item was a poster presentation at the 2009 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition held from 8-12 November 2009 in Los Angeles, USA. [2] The abstract for the poster presentation is given at: [3] AAPS Poster Number: W5393
Uncontrolled Keywords: dosator, powder flow
Subjects: R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Related URLs:
Last Modified: 17 Oct 2016 10:03
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2091

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