Modelling of dosator operation for improved manufacturing performance
Angulo Pinzon, O.A., Berry, R.J., Bradley, M.S and Antonijevic, M.D. (2009) Modelling of dosator operation for improved manufacturing performance. In: 2009 AAPS Annual Meeting and Exposition, 8-12 Nov 2009, Los Angeles, USA.Full text not available from this repository.
Purpose: To develop an improved mathematical model for the prediction of dose accuracy of Dosators - based upon the geometry of the machine in conjunction with measured flow properties of the powder.
Methods: A mathematical model has been created, based on a analytical method of differential slices - incorporating measured flow properties. The key flow properties of interest in this investigation were: flow function, effective angle of wall friction, wall adhesion, bulk density, stress ratio K and permeability. To simulate the real process and (very importantly) validate the model, a Dosator test-rig has been used to measure the forces acting on the Dosator during the filling stage, the force required to eject the dose and the dose weight.
Results: Preliminary results were obtained from the Dosator test-rig. Figure 1 [Omitted] shows the dose weight for different depths to the bottom of the powder bed at the end of the stroke and different levels of pre-compaction of the powder bed. A strong influence over dose weight arising from the proximity between the Dosator and the bottom of the powder bed at the end of the stroke and the conditions of the powder bed has been established.
Conclusions: The model will provide a useful tool to predict dosing accuracy and, thus, optimise the future design of Dosator based equipment technology – based on measured bulk properties of the powder to be handled. Another important factor (with a significant influence) on Dosator processes, is the condition of the powder bed and the clearance between the Dosator and the bottom of the powder bed.
|Item Type:||Conference or Workshop Item (Poster)|
|Additional Information:|| This item was a poster presentation at the 2009 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition held from 8-12 November 2009 in Los Angeles, USA.  The abstract for the poster presentation is given at:  AAPS Poster Number: W5393|
|Uncontrolled Keywords:||dosator, powder flow|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
T Technology > TP Chemical technology
|School / Department / Research Groups:||School of Engineering|
School of Engineering > Wolfson Centre for Bulk Solids Handling Technology
School of Science
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||12 Feb 2014 16:18|
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