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Phase behaviour of dehydrated phosphatidylcholines

Phase behaviour of dehydrated phosphatidylcholines

Owusu-Ware, Samuel K., Chowdhry, Babur Z., Leharne, Stephen A. and Antonijevic, Milan D. (2016) Phase behaviour of dehydrated phosphatidylcholines. Journal of Thermal Analysis and Calorimetry, 127 (1). pp. 415-421. ISSN 1388-6150 (Print), 1572-8943 (Online) (doi:10.1007/s10973-016-5957-x)

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Abstract

Dehydrated DLPC, DMPC, DPPC and DSPC have been characterised at temperatures below the diacyl carbon chain-melting transition (Tm), using DSC. For the first time, the existence of pre-Tm transition processes, which are, usually, only observed in the colloidal/liposomal state of saturated phospholipids have been detected for the dehydrated phosphatidylcholines. Temperature modulated differential scanning calorimetry (TMDSC) was used to characterize the several complex, overlapping pre-Tm transition processes. Kinetic studies of the chain-melting (Tm) transition show the activation energy dependence on α (conversion rate) i.e. activation energy decreases as the transition progresses, pointing to the importance of initial cooperative (intra- and inter-molecular) mobility. Furthermore the activation energy increases with increase in diacyl chain length of the phosphatidylcholines which supports the finding that greater molecular interactions of the polymer chain and its head groups in the dehydrated solid state lead to enhanced stability of dehydrated phosphatidylcholines.

Item Type: Article
Uncontrolled Keywords: Phospholipids; Dehydrated phosphatidylcholines; Differential scanning calorimetry; Phase transitions
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 25 Nov 2017 01:38
Selected for GREAT 2016: None
Selected for GREAT 2017: GREAT a
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/16000

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