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breast cancer
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302640)
bystander effect
Greco, O., Joiner, M.C., Doleh, A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302482)
cancer
Scott, S.D. and Marples, B. (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301305)
cancer gene therapy
Worthington, J., Robson, T., Scott, S. and Hirst, D. (2005) Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer. Gene Therapy, 12 (19). pp. 1417-1423. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302552)
CArG
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302640)
CArG element
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301823)
CArG elements
Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301116)
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301822)
Worthington, J., Robson, T., Scott, S. and Hirst, D. (2005) Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer. Gene Therapy, 12 (19). pp. 1417-1423. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302552)
cell-based
Muthana, M., Scott, S.D., Farrow, N., Morrow, F., Murdoch, C., Grubb, S., Brown, N., Dobson, J. and Lewis, C.E. (2008) A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy, 15 (12). pp. 902-910. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/gt.2008.57)
CMV promoter
Scott, S.D. and Marples, B. (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301305)
CRE recombinase
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:https://doi.org/10.1038/sj.gt.3301223)
cre/loxP
Scott, S.D. and Marples, B. (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301305)
DNA
Scott, S.D. and Marples, B. (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301305)
Egr1
Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301116)
fusion proteins
Greco, O., Joiner, M.C., Doleh, A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302482)
ganciclovir
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:https://doi.org/10.1038/sj.gt.3301223)
GCV
Greco, O., Joiner, M.C., Doleh, A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302482)
GDEPT
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301823)
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301822)
gene therapy
Coulter, J.A., McCarthy, H.O., Worthington, J., Robson, T., Scott, S. and Hirst, D.G. (2008) The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. Gene Therapy, 15 (7). pp. 495-503. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/gt.2008.7)
Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301116)
Muthana, M., Scott, S.D., Farrow, N., Morrow, F., Murdoch, C., Grubb, S., Brown, N., Dobson, J. and Lewis, C.E. (2008) A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy, 15 (12). pp. 902-910. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/gt.2008.57)
Scott, S.D. and Marples, B. (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301305)
GFP
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302640)
Greco, O., Joiner, M.C., Doleh, A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302482)
Marples, B., Scott, S.D., Hendry, J.H., Embleton, M.J., Lashford, L.S. and Margison, G.P. (2000) Development of synthetic promoters for radiationmediated gene therapy. Gene Therapy, 7 (6). pp. 511-517. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301116)
glioma
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302640)
Greco, O., Joiner, M.C., Doleh, A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302482)
HRE
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302640)
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301823)
HRP/IAA
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301823)
HSVtk
Greco, O., Joiner, M.C., Doleh, A. and Scott, S.D. (2005) VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12 (12). pp. 974-979. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302482)
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:https://doi.org/10.1038/sj.gt.3301223)
HSVtk/GCV
Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G. and Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Therapy, 13 (3). pp. 206-215. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302640)
inducible nitric oxide synthase
Worthington, J., Robson, T., Scott, S. and Hirst, D. (2005) Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer. Gene Therapy, 12 (19). pp. 1417-1423. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3302552)
iNOS
Coulter, J.A., McCarthy, H.O., Worthington, J., Robson, T., Scott, S. and Hirst, D.G. (2008) The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. Gene Therapy, 15 (7). pp. 495-503. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/gt.2008.7)
magnetic
Muthana, M., Scott, S.D., Farrow, N., Morrow, F., Murdoch, C., Grubb, S., Brown, N., Dobson, J. and Lewis, C.E. (2008) A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy, 15 (12). pp. 902-910. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/gt.2008.57)
molecular switch
Scott, S.D. and Marples, B. (2000) Comment on the use of the cre/loxP recombinase system for gene therapy vectors. Gene Therapy, 7 (19). p. 1706. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301305)
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:https://doi.org/10.1038/sj.gt.3301223)
pE9
Coulter, J.A., McCarthy, H.O., Worthington, J., Robson, T., Scott, S. and Hirst, D.G. (2008) The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. Gene Therapy, 15 (7). pp. 495-503. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/gt.2008.7)
promoters
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301822)
radiation
Coulter, J.A., McCarthy, H.O., Worthington, J., Robson, T., Scott, S. and Hirst, D.G. (2008) The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation. Gene Therapy, 15 (7). pp. 495-503. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/gt.2008.7)
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301822)
radiation-responsive elements
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:https://doi.org/10.1038/sj.gt.3301223)
radiotherapy
Greco, O., Marples, B., Dachs, G.U., Williams, K.J., Patterson, A.V. and Scott, S.D. (2002) Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy, 9 (20). pp. 1403-1411. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301823)
Scott, S.D., Marples, B., Hendry, J.H., Lashford, L.S., Embleton, M.J., Hunter, R.D., Howell, A. and Margison, G.P. (2000) A radiation-controlled molecular switch for use in gene therapy of cancer. Gene Therapy, 7 (13). pp. 1121-1125. (doi:https://doi.org/10.1038/sj.gt.3301223)
SRF
Scott, S.D., Joiner, M.C. and Marples, B (2002) Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9 (20). pp. 1396-1402. ISSN 0969-7128 (Print), 1476-5462 (Online) (doi:https://doi.org/10.1038/sj.gt.3301822)