Items where Author is "Spencer, John"

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1 1′-dicarbaldehyde 2 2-(Thiophen-2-yl)pyridine 3 3-dihydro-2H-indol-2-ones 3-Methylidene-Oxindoles 3-triazole-containing hydroxamic acids 4-benzodiazepin-2-ones 4-substituted methylidene oxindoles 5-benzotriazepines 6-amino-β-cyclodextrins absolute configuration activation agents aldol reaction allylic rearrangement amides amines anilines antagonist anticancer anticancer agents antimalarial antitumor agents antitumor-activity benzodiazepine benzodiazepines benzotriazepine biaryl biaryls bioinorganic bioinorganic chemistry bioorganometallic chemistry Biphenylamide derivatives biphenylamides biphenyls bond bone boronic acid Br breast-cancer C-C bond formation C-H activation cancer catalysis CC bond formation CCK CCK2 CCR5 receptor cells chelation assistance chemistry chemoselectivity chloroquine Cl or F) click chemistry complexes conference report cross coupling crystal structure Crystallization cutaneous leishmaniasis cyclic di-amino acid peptide cyclic dipeptide cyclic dipeptides cyclisation C−H bond activation dbu design dimer DKP ring conformations drug development drugs DSC enzyme inhibitors ESI estrogen-receptor modulators evaluation ferrocene ferrocene-1 ferrocene-based 1 ferrocifens flow chemistry functionalised cyclodextrins G-protein coupled receptor antagonists gastrin growth growth-factor receptor halide substituents (I HDAC inhibition and activity HDAC inhibitor HERG heterocycles HIV treatment hydrogen bonds hydroxamic acid in-vitro Indolin-2-one (oxindole) inhibitors kinase inhibitor kinase inhibitors Knoevenagel condensation lysosomal cysteine proteases Maraviroc medicinal chemistry MESG metallacycles metallocene metallodrugs metals metastasis methylidene-1 microwave microwave irradiation microwave-assisted synthesis microwave-mediated chemistry microwaves molybdenum molybdenum hexacarbonyl mono-pendant cyclodextrins monoclonal-antibody nitroarenes nitroaromatics nucleophilic substitution oncology organic organometallic chemistry organometallic complexes osteoprotegerin oxazoles oxidation reaction palladacycle palladacycle complexes palladacycles palladium palladium-catalyzed coupling parallel synthesis pharmaceuticals pi interactions pincer pincer complexes piperazine piperazines PNP enzyme Polymorphism polymorphs precatalysts progression protein pthrp ramps receptor antagonists reduction reductions ruthenium SNAr/reduction processes solid state x-ray crystallography specificity stability steric hindrance stoichiometric reducing agent submicromolar antitrypanosomal activity supported reagents Suzuki coupling Suzuki–Miyaura coupling synthesis thermal analysis Triphenylphosphine trypanosoma tuberculosis tyrosine kinase-activity x-ray crystal structure X-ray crystallography Z' � atom-economical C–H activation chemistry

Number of items: 212.

1

Spencer, John, Rathnam, Rajendra P. and Chowdhry, Babur Z. (2010) Methodology issues and design approach of VLE on mathematical concepts acquisition within secondary education in England. Future Medicinal Chemistry, 2 (9). pp. 1441-1449. ISSN 1756-8919 (doi:https://doi.org/10.4155/fmc.10.226)

1′-dicarbaldehyde

Spencer, John, Nielsen, Birthe ORCID: 0000-0002-0849-4987 , Thomas, Michael J.K., Male, Louise and Coles, Simon J. (2011) The Knoevenagel product of indolin-2-one and ferrocene-1,1′-dicarbaldehyde. Acta Crystallographica Section C, 67 (7). m245-m248. ISSN 0108-2701 (doi:https://doi.org/10.1107/S0108270111021536)

2

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:https://doi.org/10.1039/c1md00203a)

2-(Thiophen-2-yl)pyridine

Callear, Samantha K., Spencer, John, Patel, Hiren, Deadman, John J. and Hursthouse, Michael B. (2010) Crystal structures of two palladacycles from the C-H activation of 2-(Thiophen-2-yl)pyridine. Journal of Chemical Crystallography, 41 (4). pp. 523-527. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-010-9913-5)

3 3-dihydro-2H-indol-2-ones

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:https://doi.org/10.1039/C1MT00017A)

3-Methylidene-Oxindoles

Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (Print), 1520-6041 (Online) (doi:https://doi.org/10.1021/om200278j)

3-triazole-containing hydroxamic acids

4-benzodiazepin-2-ones

4-substituted methylidene oxindoles

Tizzard, Graham J., Coles, Simon J., Edwards, Mark, Onyeabo, Romanus Oforbike, Allen, Mark and Spencer, John (2013) Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles. Chemistry Central Journal, 7 (1):182. ISSN 1752-153X (doi:https://doi.org/10.1186/1752-153X-7-182)

5-benzotriazepines

6-amino-β-cyclodextrins

Puglisi, Antonino, Spencer, John, Clark, James and Milton, John (2011) Microwave-assisted synthesis of 6-amino-β-cyclodextrins. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 73 (1-4). pp. 475-478. ISSN 0923-0750 (Print), 1573-1111 (Online) (doi:https://doi.org/10.1007/s10847-011-0054-z)

absolute configuration

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0098-3)

activation

Spencer, John, Mendham, Andrew P., Kotha, Arun K., Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Hillard, Elizabeth A., Jaouen, Gérard, Male, Louise and Hursthouse, Michael B. (2008) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transactions, 2009 (6). pp. 918-921. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/B816249B)

agents

Spencer, John, Rathnam, Rajendra P., Montukuri, Mahesh, Kotha, Arun K., Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Hazrati, Ali, Hartley, John A., Male, Louise and Hursthouse, Michael B. (2009) Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. Dalton Transactions (22). pp. 4299-4303. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/b819061e)

aldol reaction

Spencer, John (2008) Other uses of palladacycles in synthesis. In: Dupont, Jairton and Pfeffer, Michel, (eds.) Palladacycles. Wiley-VCH, Weinheim, pp. 227-238. ISBN 9783527317813 (Print) 9783527623211 (Online) (doi:https://doi.org/10.1002/9783527623211.ch10)

allylic rearrangement

amides

Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia ORCID: 0000-0003-1402-8496 , Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:https://doi.org/10.1016/j.tetlet.2012.05.025)

amines

Spencer, John, Rathnam, Rajendra, Patel, Hiren and Anjum, Nazira (2008) Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo(CO)(6) and DBU. Tetrahedron, 64 (44). pp. 10195-10200. ISSN 0040-4020 (doi:https://doi.org/10.1016/j.tet.2008.08.036)

Spencer, John, Anjum, Nazira, Patel, Hiren, Rathnam, Rajendra and Verma, Jason (2007) Molybdenum hexacarbonyl and DBU reduction of nitro compounds under microwave irradiation. Synlett, 2007 (16). pp. 2557-2558. ISSN 0936-5214 (doi:https://doi.org/10.1055/s-2007-986628)

anilines

Spencer, John (2010) Microwave chemistry enabling the synthesis of biologically relevant amines. Future Medicinal Chemistry, 2 (2). pp. 161-168. ISSN 1756-8919 (Print), 1756-8927 (Online) (doi:https://doi.org/10.4155/fmc.09.114)

Spencer, John (2010) Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines. Future Medicinal Chemistry, 2 (2). pp. 161-168. ISSN 1756-8919 (Print), 1756-8927 (Online) (doi:https://doi.org/10.4155/fmc.09.114)

antagonist

Spencer, John, Gaffen, John, Grifin, Eric, Harper, Elaine A., Linney, Ian D., McDonald, Iain M., Roberts, Sonia P., Shaxted, Mark E., Adatia, Trushar and Bashall, Alan (2008) Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template. Bioorganic & Medicinal Chemistry, 16 (6). pp. 2974-2983. ISSN 0968-0896 (doi:https://doi.org/10.1016/j.bmc.2007.12.047)

anticancer

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875 (doi:10.1021.ml100295v)

anticancer agents

Spencer, John, Rathnam, Rajendra P. and Chowdhry, Babur Z. (2010) 1,4-Benzodiazipine-2-ones in medicinal chemistry. Future Medicinal Chemistry, 2 (9). pp. 1441-1449. ISSN 1756-8919 (doi:https://doi.org/10.4155/fmc.10.226)

antimalarial

antitumor agents

Leyva, Lida, Sirlin, Claude, Rubio, Laura, Franco, Cecilia, Le Lagadec, Ronan, Spencer, John, Bischoff, Pierre, Gaiddon, Christian, Loeffler, Jean-Philippe and Pfeffer, Michel (2007) Synthesis of cycloruthenated compounds as potential anticancer agents. European Journal of Inorganic Chemistry, 2007 (19). pp. 3055-3066. ISSN 1434-1948 (doi:https://doi.org/10.1002/ejic.200601149)

antitumor-activity

benzodiazepine

Parbhu Patel, Asha, Deacon, Andrew D., Spencer, John, Raj, Rathnam, Harbige, Laurence and Getti, Giulia ORCID: 0000-0003-1402-8496 (2010) The benzodiazepine class of compounds as a potential for the treatment of cutaneous leishmaniasis. In: XII International Congress of Parasitology ICOPA, 15 - 20 Aug 2010, Melbourne, Australia. (Unpublished)

Spencer, John, Chowdhry, Babur Z., Mallet, Anthony I., Rathnam, Rajendra P., Adatia, Trushar, Bashall, Alan and Rominger, Frank (2008) C-H activations on a 1H-1,4-benzodiazepin-2(3H)-one template. Tetrahedron, 64 (26). pp. 6082-6089. ISSN 0040-4020 (doi:https://doi.org/10.1016/j.tet.2008.01.059)

benzodiazepines

Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:https://doi.org/10.1016/j.bmc.2011.01.010)

benzotriazepine

biaryl

Spencer, John, Baltus, Christine B., Press, Neil J., Harrington, Ross W. and Clegg, William (2011) Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings. Tetrahedron Letters, 52 (31). pp. 3963-3968. ISSN 0040-4039 (online) (doi:https://doi.org/10.1016/j.tetlet.2011.05.025)

biaryls

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:https://doi.org/10.1021/co100011g)

bioinorganic

bioinorganic chemistry

bioorganometallic chemistry

Spencer, John, Casini, Angela, Zava, Olivier, Rathnam, Rajendra P., Velhanda, Santosh K., Pfeffer, Michel, Callear, Samantha K., Hursthouse, Michael B. and Dyson, Paul J. (2009) Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles. Dalton Transactions (48). pp. 10731-10735. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/b912096c)

Biphenylamide derivatives

Owusu-Ware, Samuel K., Cherry, Anthony J., Baltus, Christine B., Spencer, John and Antonijevic, Milan D. ORCID: 0000-0002-5847-7886 (2015) Thermal analysis of novel biphenylamide derivatives: influence of positional and functional group isomerism on solid state properties. Journal of Thermal Analysis and Calorimetry, 121 (1). pp. 437-452. ISSN 1388-6150 (Print), 1588-2926 (Online) (doi:https://doi.org/10.1007/s10973-015-4628-7)

biphenylamides

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: 0000-0002-5847-7886 , Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:https://doi.org/10.1016/j.tet.2012.08.062)

biphenyls

Owusu-Ware, Samuel K., Masud, Mohammed, Baltus, Christine, Spencer, John and Antonijevic, Milan ORCID: 0000-0002-5847-7886 (2011) Thermal stability implication of positional isomerism of novel biphenyl derivatives. In: 2011 AAPS Annual Meeting and Exposition, 23-27 Oct 2011, Washington Convention Center, Washington, D.C., USA. (Unpublished)

bond

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:https://doi.org/10.1107/S0108270109054134)

bone

McDonald, Iain M., Austin, Carol, Buck, Ildiko M., Dunstone, David J., Gaffen, John, Griffin, Eric, Harper, Elaine A., Hull, Robert A.D., Kalindjian, S. Barret, Linney, Ian D., Low, Caroline M.R., Patel, Dipa, Pether, Michael J., Raynor, Michelle, Roberts, Sonia P., Shaxted, Mark E., Spencer, John, Steel, Katherine I.M., Sykes, David A., Wright, Paul T. and Xun, Wei (2007) [Letter] Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists. Journal of Medicinal Chemistry, 50 (20). pp. 4789-4792. ISSN 0022-2623 (Print), 1520-4804 (Online) (doi:https://doi.org/10.1021/jm0707626)

boronic acid

Br

breast-cancer

C-C bond formation

Spencer, John (2008) C-H activations via palladacycles. In: Dupont, Jairton and Pfeffer, Michel, (eds.) Palladacycles. Wiley-VCH, Weinheim, pp. 109-121. ISBN 9783527317813 (Print) 9783527623211 (Online) (doi:https://doi.org/10.1002/9783527623211.ch6)

C-H activation

cancer

Spencer, John (2009) Current metallodrugs in cancer. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

catalysis

CC bond formation

CCK

CCK2

CCR5 receptor

Spencer, John (2009) Case study on Maraviroc, a CCR5 Antagonist for HIV treatment. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

cells

chelation assistance

chemistry

Puglisi, Antonino, Spencer, John, Oliveri, Valentina, Vecchio, Graziella, Kong, Xiaole, Clarke, James and Milton, John (2011) Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(iii) complexes. Dalton Transactions, 41 (10). pp. 2877-2883. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/c1dt11677k)

chemoselectivity

chloroquine

Cl or F)

click chemistry

complexes

conference report

Spencer, John (2010) Conference report: 7th Annual Congress of International Drug Discovery Science and Technology. Future Medicinal Chemistry, 2 (1). pp. 21-23. ISSN 1756-8919 (doi:https://doi.org/10.4155/FMC.09.151)

cross coupling

crystal structure

Crystallization

cutaneous leishmaniasis

cyclic di-amino acid peptide

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0097-4)

cyclic dipeptide

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0097-4)

cyclic dipeptides

cyclisation

C−H bond activation

dbu

design

dimer

DKP ring conformations

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0097-4)

drug development

drugs

DSC

enzyme inhibitors

ESI

Neto, Brenno A.D., Lapis, Alexandre A.M., Netz, Paulo A., Spencer, John, Dias, Silvio L.P., Tamborim, Silvia M., Basso, Luiz A., Santos, Diógenes S. and Dupont, Jairton (2010) Synthesis and enzymatic evaluation of the guanosine analogue 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG): insights into the phosphorolysis reaction mechanism based on the blueprint transition state: SN1 or SN2? Journal of the Brazilian Chemical Society, 21 (1). pp. 151-156. ISSN 0103-5053 (Print), 1678-4790 (Online) (doi:https://doi.org/10.1590/S0103-50532010000100022)

estrogen-receptor modulators

evaluation

ferrocene

ferrocene-1

ferrocene-based 1

ferrocifens

flow chemistry

Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:https://doi.org/10.1016/j.tetlet.2012.01.081)

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:https://doi.org/10.1016/j.tetlet.2011.07.147)

functionalised cyclodextrins

G-protein coupled receptor antagonists

gastrin

growth

growth-factor receptor

halide substituents (I

HDAC inhibition and activity

HDAC inhibitor

HERG

heterocycles

HIV treatment

hydrogen bonds

hydroxamic acid

in-vitro

Indolin-2-one (oxindole)

inhibitors

kinase inhibitor

kinase inhibitors

Knoevenagel condensation

lysosomal cysteine proteases

Maraviroc

medicinal chemistry

Spencer, John (2009) Microwave technology applied to medicinal chemistry. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

MESG

metallacycles

metallocene

metallodrugs

Spencer, John (2009) Current metallodrugs in cancer. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

metals

Spencer, John (2009) Current metallodrugs in cancer. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

metastasis

methylidene-1

microwave

microwave irradiation

microwave-assisted synthesis

microwave-mediated chemistry

microwaves

molybdenum

molybdenum hexacarbonyl

mono-pendant cyclodextrins

monoclonal-antibody

nitroarenes

nitroaromatics

nucleophilic substitution

oncology

Spencer, John (2009) Current metallodrugs in cancer. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

organic

organometallic chemistry

organometallic complexes

Dupont, Jairton, Consorti, C. and Spencer, John (2007) Organometallic pincer-type complexes: recent applications in synthesis and catalysis. In: Morales-Morales, David and Jensen, Craig M., (eds.) The Chemistry of Pincer Compounds. Elsevier, Amsterdam, pp. 1-24. ISBN 9780444531384 (doi:https://doi.org/10.1016/B978-044453138-4/50002-7)

osteoprotegerin

oxazoles

oxidation reaction

palladacycle

palladacycle complexes

palladacycles

palladium

palladium-catalyzed coupling

parallel synthesis

pharmaceuticals

pi interactions

pincer

pincer complexes

piperazine

piperazines

PNP enzyme

Polymorphism

polymorphs

precatalysts

progression

protein

pthrp

ramps

receptor antagonists

reduction

reductions

ruthenium

SNAr/reduction processes

solid state x-ray crystallography

specificity

stability

steric hindrance

stoichiometric reducing agent

submicromolar antitrypanosomal activity

supported reagents

Suzuki coupling

Suzuki–Miyaura coupling

synthesis

Spencer, John (2009) Combinatorial and parallel synthesis. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, pp. 307-331. ISBN 9780199234479

thermal analysis

Triphenylphosphine

trypanosoma

tuberculosis

tyrosine kinase-activity

x-ray crystal structure

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0097-4)

X-ray crystallography

Z'

� atom-economical C–H activation chemistry

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