bone metastasis

Zhou, Jiabao, Down, Jennifer M, George, Christopher N, Murphy, Jessica, Lefley, Diane V, Tulotta, Claudia, Alsharif, Marwa A, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325 and Ottewell, Penelope D (2022) Novel methods of targeting IL-1 signalling for the treatment of breast cancer bone metastasis. Cancers, 14 (19):4816. ISSN 2072-6694 (Online) (doi:10.3390/cancers14194816)

breast cancer

Zhou, Jiabao, Down, Jennifer M, George, Christopher N, Murphy, Jessica, Lefley, Diane V, Tulotta, Claudia, Alsharif, Marwa A, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325 and Ottewell, Penelope D (2022) Novel methods of targeting IL-1 signalling for the treatment of breast cancer bone metastasis. Cancers, 14 (19):4816. ISSN 2072-6694 (Online) (doi:10.3390/cancers14194816)

CEN-092

Walsh, Yvonne, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325, Veale, Emma and Mathie, Alistair (2021) Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine, and CEN-092. Biochemistry and Biophysics Reports, 26:101021. ISSN 2405-5808 (doi:10.1016/j.bbrep.2021.101021)

central nervous system

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. JP2011144195.

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. EP2324828 (A1).

Cyclic Triazo Sodium channel blockers

University of Greenwich (2017) HK1170726 (A1)2017-06-02 Cyclic triazo sodium channel blockers. HK1179726 (A1).

cytokine release syndrome

Leach, Michael, and Williams, Paul, University of Greenwich (2023) Diazine and triazine compounds to treat cytokine storm syndrome US 2023/0165869 A1. US2023/0165869A1.

cytokine storm

Leach, Michael, and Paul Williams (University of Greenwich) (2023) Triazines as inhibitors of cytokine storm and cytokine storm syndrome (JP2023522444A). .

Leach, Michael, and Williams, Paul, University of Greenwich (2021) Diazine and triazine compounds to treat cytokine storm syndrome. WO2016198878A1.

cytokine storm syndrome

Leach, Michael, and Williams, Paul, University of Greenwich (2023) Diazine and triazine compounds to treat cytokine storm syndrome US 2023/0165869 A1. US2023/0165869A1.

Leach, Michael, and Paul Williams (University of Greenwich) (2023) Triazines as inhibitors of cytokine storm and cytokine storm syndrome (JP2023522444A). .

cytokines

Leach, Michael, and Williams, Paul, University of Greenwich (2021) Diazine and triazine compounds to treat cytokine storm syndrome. WO2016198878A1.

University of Greenwich (2016) Triazine derivatives as interferon gamma inhibitors. WO 2016/109978 A1.

diazines

Leach, Michael, and Williams, Paul, University of Greenwich (2021) Diazine and triazine compounds to treat cytokine storm syndrome. WO2016198878A1.

IL-1beta

Zhou, Jiabao, Down, Jennifer M, George, Christopher N, Murphy, Jessica, Lefley, Diane V, Tulotta, Claudia, Alsharif, Marwa A, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325 and Ottewell, Penelope D (2022) Novel methods of targeting IL-1 signalling for the treatment of breast cancer bone metastasis. Cancers, 14 (19):4816. ISSN 2072-6694 (Online) (doi:10.3390/cancers14194816)

Interferon gamma

University of Greenwich (2016) Triazine derivatives as interferon gamma inhibitors. WO 2016/109978 A1.

Interferon gamma inhibitors

University of Greenwich (2018) Triazine derivatives as interferon gamma inhibitors. US2018169105.

University of Greenwich (2018) Triazine derivatives as interferon gamma inhibitors. EP 3307273 (A1).

interleukin inhibitors

Leach, Michael, and Paul Williams (University of Greenwich) (2023) Triazines as Interleukin Inhibitors (JP2023522436A). .

University of Greenwich (2021) Interleukin Inhibitors. WO2021/214494 A1.

K2P cannel

Walsh, Yvonne, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325, Veale, Emma and Mathie, Alistair (2021) Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine, and CEN-092. Biochemistry and Biophysics Reports, 26:101021. ISSN 2405-5808 (doi:10.1016/j.bbrep.2021.101021)

lamotrigine

Walsh, Yvonne, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325, Veale, Emma and Mathie, Alistair (2021) Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine, and CEN-092. Biochemistry and Biophysics Reports, 26:101021. ISSN 2405-5808 (doi:10.1016/j.bbrep.2021.101021)

medical use

University of Greenwich, Old Royal Naval College Park Row, Greenwich, London SE10 9LS (2008) New medical use of triazine derivatives. WO/2008/007149.

multiple sclerosis

University of Greenwich (2015) Medical uses of triazines. .

University of Greenwich, UK (2015) US9000155: Cyclic triazo sodium channel blockers. .

University of Greenwich, UK (2015) AU2014280981: Cyclic Triazo and Diazo channel blockers. .

Michael Leach (2014) US2014243343 (A1)Cyclic triazo sodium channel blockers. .

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. JP2011144195.

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. EP2324828 (A1).

Neurodegeneration

University of Greenwich, London UK (2014) HK1129206 (A1): New medical use of triazine derivatives. .

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. JP2011144195.

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. EP2324828 (A1).

Neurodegenerative disease

University of Greenwich (2015) Medical uses of triazines. .

Neurodegenerative disorders

University of Greenwich, UK (2015) US9000155: Cyclic triazo sodium channel blockers. .

Neurological disorders

Michael Leach (2014) US2014243343 (A1)Cyclic triazo sodium channel blockers. .

Neuroprotection

University of Greenwich (2016) Cyclic triazo and diazo sodium channel blockers US divisional. US2016/0311784A1.

University of Greenwich, London UK (2014) ES24629727 (T3): New medical use of triazines. .

University of Greenwich, UK (2012) KR20120048593 Cyclic triazo sodium channel blockers. KR20120048593 (A).

Neuroprotection Sodium channels Multiple sclerosis

University of Greenwich, London, UK (2014) US2014155403 Cyclic triazo and diazo sodium channel blockers. .

Neuroprotective

University of Greenwich, UK (2015) AU2014280981: Cyclic Triazo and Diazo channel blockers. .

polyunsaturated fatty acids

BTG International Ltd (2010) Treatment of neurodegenerative conditions. US2010/0113810 A1.

Sipatrigine

Walsh, Yvonne, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325, Veale, Emma and Mathie, Alistair (2021) Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine, and CEN-092. Biochemistry and Biophysics Reports, 26:101021. ISSN 2405-5808 (doi:10.1016/j.bbrep.2021.101021)

Sodium channel blockers

University of Greenwich (2018) Triazine derivatives as interferon gamma inhibitors. US2018169105.

University of Greenwich (2016) Cyclic triazo and diazo sodium channel blockers US divisional. US2016/0311784A1.

University of Greenwich, London UK (2014) HK1129206 (A1): New medical use of triazine derivatives. .

Michael Leach (2014) US2014243343 (A1)Cyclic triazo sodium channel blockers. .

University of Greenwich, London UK (2014) ES24629727 (T3): New medical use of triazines. .

University of Greenwich, UK (2012) KR20120048593 Cyclic triazo sodium channel blockers. KR20120048593 (A).

University of Greenwich, Old Royal Naval College Park Row, Greenwich London SE10 9LS (2009) Cyclic triazo and diazo sodium channel blockers. WO/2009/090431.

treatment of multiple sclerosis

BTG International Ltd (2010) Treatment of neurodegenerative conditions. US2010/0113810 A1.

TREK channel

Walsh, Yvonne, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325, Veale, Emma and Mathie, Alistair (2021) Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine, and CEN-092. Biochemistry and Biophysics Reports, 26:101021. ISSN 2405-5808 (doi:10.1016/j.bbrep.2021.101021)

TRESK channel

Walsh, Yvonne, Leach, Michael ORCID: https://orcid.org/0000-0002-9859-1325, Veale, Emma and Mathie, Alistair (2021) Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine, and CEN-092. Biochemistry and Biophysics Reports, 26:101021. ISSN 2405-5808 (doi:10.1016/j.bbrep.2021.101021)

triazine derivatives

University of Greenwich (2018) Triazine derivatives as interferon gamma inhibitors. EP 3307273 (A1).

triazines

Leach, Michael, and Paul Williams (University of Greenwich) (2023) Triazines as inhibitors of cytokine storm and cytokine storm syndrome (JP2023522444A). .

Leach, Michael, and Williams, Paul, University of Greenwich (2021) Diazine and triazine compounds to treat cytokine storm syndrome. WO2016198878A1.

University of Greenwich (2018) Triazine derivatives as interferon gamma inhibitors. US2018169105.

University of Greenwich (2016) Triazine derivatives as interferon gamma inhibitors. WO 2016/109978 A1.

University of Greenwich, UK (2015) US9000155: Cyclic triazo sodium channel blockers. .

University of Greenwich, London UK (2014) HK1129206 (A1): New medical use of triazine derivatives. .

University of Greenwich, Old Royal Naval College Park Row, Greenwich London SE10 9LS (2009) Cyclic triazo and diazo sodium channel blockers. WO/2009/090431.

University of Greenwich, Old Royal Naval College Park Row, Greenwich, London SE10 9LS (2008) New medical use of triazine derivatives. WO/2008/007149.

uveitis

University of Greenwich (2015) Medical uses of triazines. .

Uveitis and other diseases

University of Greenwich, UK (2015) AU2014280981: Cyclic Triazo and Diazo channel blockers. .