animal models of autism

Granak, Simon, Tuckova, Klara, Kutna, Viera, Vijtechova, Iveta, Bajkova, Laura, Petrasek, Tomas and Ovsepian, Saak (2022) Developmental effects of the impact of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder. European Journal of Neuroscience, 57 (1). pp. 17-31. ISSN 0953-816X (Print), 1460-9568 (Online) (doi:10.1111/ejn.15864)

antidepressants

Dremencov, Eliyahu ORCID: https://orcid.org/0000-0001-8103-8577, Jezova, Daniela, Barak, Segev ORCID: https://orcid.org/0000-0002-3143-6777, Gaburjakova, Jana, Gaburjakova, Marta, Kutna, Viera and Ovsepian, Saak V. (2021) Trophic factors as potential therapies for treatment of major mental disorders. Neuroscience Letters, 764:136194. ISSN 0304-3940 (doi:10.1016/j.neulet.2021.136194)

antipsychotics

Dremencov, Eliyahu ORCID: https://orcid.org/0000-0001-8103-8577, Jezova, Daniela, Barak, Segev ORCID: https://orcid.org/0000-0002-3143-6777, Gaburjakova, Jana, Gaburjakova, Marta, Kutna, Viera and Ovsepian, Saak V. (2021) Trophic factors as potential therapies for treatment of major mental disorders. Neuroscience Letters, 764:136194. ISSN 0304-3940 (doi:10.1016/j.neulet.2021.136194)

autism spectrum disorder

Kutna, Viera, O'Leary, Valerie Brid, Hoschl, Cyril and Ovsepian, Saak V. (2022) Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model. Autism Research, 15 (5). pp. 791-805. ISSN 1939-3792 (Print), 1939-3806 (Online) (doi:10.1002/aur.2688)

autism spectrum disorders

Yenkoyan, Konstantin, Grigoryan, Artem, Kutna, Viera, Shorter, Susan, O'Leary, Valerie B, Asadollahi, Reza ORCID: https://orcid.org/0000-0002-1497-0564 and Ovsepian, Saak V. (2024) Cerebellar impairments in genetic models of autism spectrum disorders: a neurobiological perspective. Progress in Neurobiology, 242:102685. ISSN 0301-0082 (Print), 1873-5118 (Online) (doi:10.1016/j.pneurobio.2024.102685)

Kutna, Viera, O'Leary, Valerie, Newman, Ehren, Hoschl, Cyril and Ovsepian, Saak (2021) Revisiting brain tuberous sclerosis complex in rat and human: shared molecular and cellular pathology leads to distinct neurophysiological and behavioural phenotypes. Neurotherapeutics - The Journal of the American Society for Experimental Neurotherapeutics, 18 (2). pp. 845-858. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:10.1007/s13311-020-01000-7)

cerebellum

Yenkoyan, Konstantin, Grigoryan, Artem, Kutna, Viera, Shorter, Susan, O'Leary, Valerie B, Asadollahi, Reza ORCID: https://orcid.org/0000-0002-1497-0564 and Ovsepian, Saak V. (2024) Cerebellar impairments in genetic models of autism spectrum disorders: a neurobiological perspective. Progress in Neurobiology, 242:102685. ISSN 0301-0082 (Print), 1873-5118 (Online) (doi:10.1016/j.pneurobio.2024.102685)

Kutna, Viera, O'Leary, Valerie Brid, Hoschl, Cyril and Ovsepian, Saak V. (2022) Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model. Autism Research, 15 (5). pp. 791-805. ISSN 1939-3792 (Print), 1939-3806 (Online) (doi:10.1002/aur.2688)

cingulate gyrus

Granak, Simon, Tuckova, Klara, Kutna, Viera, Vijtechova, Iveta, Bajkova, Laura, Petrasek, Tomas and Ovsepian, Saak (2022) Developmental effects of the impact of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder. European Journal of Neuroscience, 57 (1). pp. 17-31. ISSN 0953-816X (Print), 1460-9568 (Online) (doi:10.1111/ejn.15864)

demyelination

Kutna, Viera, O'Leary, Valerie Brid, Hoschl, Cyril and Ovsepian, Saak V. (2022) Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model. Autism Research, 15 (5). pp. 791-805. ISSN 1939-3792 (Print), 1939-3806 (Online) (doi:10.1002/aur.2688)

dendritic spine

Granak, Simon, Tuckova, Klara, Kutna, Viera, Vijtechova, Iveta, Bajkova, Laura, Petrasek, Tomas and Ovsepian, Saak (2022) Developmental effects of the impact of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder. European Journal of Neuroscience, 57 (1). pp. 17-31. ISSN 0953-816X (Print), 1460-9568 (Online) (doi:10.1111/ejn.15864)

Eker rats

Granak, Simon, Tuckova, Klara, Kutna, Viera, Vijtechova, Iveta, Bajkova, Laura, Petrasek, Tomas and Ovsepian, Saak (2022) Developmental effects of the impact of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder. European Journal of Neuroscience, 57 (1). pp. 17-31. ISSN 0953-816X (Print), 1460-9568 (Online) (doi:10.1111/ejn.15864)

enriched environment

Granak, Simon, Tuckova, Klara, Kutna, Viera, Vijtechova, Iveta, Bajkova, Laura, Petrasek, Tomas and Ovsepian, Saak (2022) Developmental effects of the impact of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder. European Journal of Neuroscience, 57 (1). pp. 17-31. ISSN 0953-816X (Print), 1460-9568 (Online) (doi:10.1111/ejn.15864)

Fmr1

Yenkoyan, Konstantin, Grigoryan, Artem, Kutna, Viera, Shorter, Susan, O'Leary, Valerie B, Asadollahi, Reza ORCID: https://orcid.org/0000-0002-1497-0564 and Ovsepian, Saak V. (2024) Cerebellar impairments in genetic models of autism spectrum disorders: a neurobiological perspective. Progress in Neurobiology, 242:102685. ISSN 0301-0082 (Print), 1873-5118 (Online) (doi:10.1016/j.pneurobio.2024.102685)

Growth factor

Dremencov, Eliyahu ORCID: https://orcid.org/0000-0001-8103-8577, Jezova, Daniela, Barak, Segev ORCID: https://orcid.org/0000-0002-3143-6777, Gaburjakova, Jana, Gaburjakova, Marta, Kutna, Viera and Ovsepian, Saak V. (2021) Trophic factors as potential therapies for treatment of major mental disorders. Neuroscience Letters, 764:136194. ISSN 0304-3940 (doi:10.1016/j.neulet.2021.136194)

hamartoma

Kutna, Viera, O'Leary, Valerie, Newman, Ehren, Hoschl, Cyril and Ovsepian, Saak (2021) Revisiting brain tuberous sclerosis complex in rat and human: shared molecular and cellular pathology leads to distinct neurophysiological and behavioural phenotypes. Neurotherapeutics - The Journal of the American Society for Experimental Neurotherapeutics, 18 (2). pp. 845-858. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:10.1007/s13311-020-01000-7)

Mecp2

Yenkoyan, Konstantin, Grigoryan, Artem, Kutna, Viera, Shorter, Susan, O'Leary, Valerie B, Asadollahi, Reza ORCID: https://orcid.org/0000-0002-1497-0564 and Ovsepian, Saak V. (2024) Cerebellar impairments in genetic models of autism spectrum disorders: a neurobiological perspective. Progress in Neurobiology, 242:102685. ISSN 0301-0082 (Print), 1873-5118 (Online) (doi:10.1016/j.pneurobio.2024.102685)

microglia activation

Kutna, Viera, O'Leary, Valerie Brid, Hoschl, Cyril and Ovsepian, Saak V. (2022) Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model. Autism Research, 15 (5). pp. 791-805. ISSN 1939-3792 (Print), 1939-3806 (Online) (doi:10.1002/aur.2688)

mTOR signalling

Kutna, Viera, O'Leary, Valerie, Newman, Ehren, Hoschl, Cyril and Ovsepian, Saak (2021) Revisiting brain tuberous sclerosis complex in rat and human: shared molecular and cellular pathology leads to distinct neurophysiological and behavioural phenotypes. Neurotherapeutics - The Journal of the American Society for Experimental Neurotherapeutics, 18 (2). pp. 845-858. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:10.1007/s13311-020-01000-7)

mTORC1 signaling

Kutna, Viera, O'Leary, Valerie Brid, Hoschl, Cyril and Ovsepian, Saak V. (2022) Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model. Autism Research, 15 (5). pp. 791-805. ISSN 1939-3792 (Print), 1939-3806 (Online) (doi:10.1002/aur.2688)

neoplasia

Kutna, Viera, O'Leary, Valerie, Newman, Ehren, Hoschl, Cyril and Ovsepian, Saak (2021) Revisiting brain tuberous sclerosis complex in rat and human: shared molecular and cellular pathology leads to distinct neurophysiological and behavioural phenotypes. Neurotherapeutics - The Journal of the American Society for Experimental Neurotherapeutics, 18 (2). pp. 845-858. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:10.1007/s13311-020-01000-7)

neuropsychiatry

Dremencov, Eliyahu ORCID: https://orcid.org/0000-0001-8103-8577, Jezova, Daniela, Barak, Segev ORCID: https://orcid.org/0000-0002-3143-6777, Gaburjakova, Jana, Gaburjakova, Marta, Kutna, Viera and Ovsepian, Saak V. (2021) Trophic factors as potential therapies for treatment of major mental disorders. Neuroscience Letters, 764:136194. ISSN 0304-3940 (doi:10.1016/j.neulet.2021.136194)

Nlgn3/4

Yenkoyan, Konstantin, Grigoryan, Artem, Kutna, Viera, Shorter, Susan, O'Leary, Valerie B, Asadollahi, Reza ORCID: https://orcid.org/0000-0002-1497-0564 and Ovsepian, Saak V. (2024) Cerebellar impairments in genetic models of autism spectrum disorders: a neurobiological perspective. Progress in Neurobiology, 242:102685. ISSN 0301-0082 (Print), 1873-5118 (Online) (doi:10.1016/j.pneurobio.2024.102685)

open field test

Granak, Simon, Tuckova, Klara, Kutna, Viera, Vijtechova, Iveta, Bajkova, Laura, Petrasek, Tomas and Ovsepian, Saak (2022) Developmental effects of the impact of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder. European Journal of Neuroscience, 57 (1). pp. 17-31. ISSN 0953-816X (Print), 1460-9568 (Online) (doi:10.1111/ejn.15864)

polyplex nanoparticles

Dremencov, Eliyahu ORCID: https://orcid.org/0000-0001-8103-8577, Jezova, Daniela, Barak, Segev ORCID: https://orcid.org/0000-0002-3143-6777, Gaburjakova, Jana, Gaburjakova, Marta, Kutna, Viera and Ovsepian, Saak V. (2021) Trophic factors as potential therapies for treatment of major mental disorders. Neuroscience Letters, 764:136194. ISSN 0304-3940 (doi:10.1016/j.neulet.2021.136194)

purkinje neurons

Yenkoyan, Konstantin, Grigoryan, Artem, Kutna, Viera, Shorter, Susan, O'Leary, Valerie B, Asadollahi, Reza ORCID: https://orcid.org/0000-0002-1497-0564 and Ovsepian, Saak V. (2024) Cerebellar impairments in genetic models of autism spectrum disorders: a neurobiological perspective. Progress in Neurobiology, 242:102685. ISSN 0301-0082 (Print), 1873-5118 (Online) (doi:10.1016/j.pneurobio.2024.102685)

Kutna, Viera, O'Leary, Valerie Brid, Hoschl, Cyril and Ovsepian, Saak V. (2022) Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model. Autism Research, 15 (5). pp. 791-805. ISSN 1939-3792 (Print), 1939-3806 (Online) (doi:10.1002/aur.2688)

refractory epilepsy

Kutna, Viera, O'Leary, Valerie, Newman, Ehren, Hoschl, Cyril and Ovsepian, Saak (2021) Revisiting brain tuberous sclerosis complex in rat and human: shared molecular and cellular pathology leads to distinct neurophysiological and behavioural phenotypes. Neurotherapeutics - The Journal of the American Society for Experimental Neurotherapeutics, 18 (2). pp. 845-858. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:10.1007/s13311-020-01000-7)

synaptophysin

Kutna, Viera, O'Leary, Valerie Brid, Hoschl, Cyril and Ovsepian, Saak V. (2022) Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model. Autism Research, 15 (5). pp. 791-805. ISSN 1939-3792 (Print), 1939-3806 (Online) (doi:10.1002/aur.2688)

targeted delivery

Dremencov, Eliyahu ORCID: https://orcid.org/0000-0001-8103-8577, Jezova, Daniela, Barak, Segev ORCID: https://orcid.org/0000-0002-3143-6777, Gaburjakova, Jana, Gaburjakova, Marta, Kutna, Viera and Ovsepian, Saak V. (2021) Trophic factors as potential therapies for treatment of major mental disorders. Neuroscience Letters, 764:136194. ISSN 0304-3940 (doi:10.1016/j.neulet.2021.136194)

TSC1

Kutna, Viera, O'Leary, Valerie, Newman, Ehren, Hoschl, Cyril and Ovsepian, Saak (2021) Revisiting brain tuberous sclerosis complex in rat and human: shared molecular and cellular pathology leads to distinct neurophysiological and behavioural phenotypes. Neurotherapeutics - The Journal of the American Society for Experimental Neurotherapeutics, 18 (2). pp. 845-858. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:10.1007/s13311-020-01000-7)

Tsc1/2

Yenkoyan, Konstantin, Grigoryan, Artem, Kutna, Viera, Shorter, Susan, O'Leary, Valerie B, Asadollahi, Reza ORCID: https://orcid.org/0000-0002-1497-0564 and Ovsepian, Saak V. (2024) Cerebellar impairments in genetic models of autism spectrum disorders: a neurobiological perspective. Progress in Neurobiology, 242:102685. ISSN 0301-0082 (Print), 1873-5118 (Online) (doi:10.1016/j.pneurobio.2024.102685)

TSC2

Kutna, Viera, O'Leary, Valerie, Newman, Ehren, Hoschl, Cyril and Ovsepian, Saak (2021) Revisiting brain tuberous sclerosis complex in rat and human: shared molecular and cellular pathology leads to distinct neurophysiological and behavioural phenotypes. Neurotherapeutics - The Journal of the American Society for Experimental Neurotherapeutics, 18 (2). pp. 845-858. ISSN 1933-7213 (Print), 1878-7479 (Online) (doi:10.1007/s13311-020-01000-7)

tuberous sclerosis complex

Granak, Simon, Tuckova, Klara, Kutna, Viera, Vijtechova, Iveta, Bajkova, Laura, Petrasek, Tomas and Ovsepian, Saak (2022) Developmental effects of the impact of constitutive mTORC1 hyperactivity and environmental enrichment on structural synaptic plasticity and behaviour in a rat model of autism spectrum disorder. European Journal of Neuroscience, 57 (1). pp. 17-31. ISSN 0953-816X (Print), 1460-9568 (Online) (doi:10.1111/ejn.15864)