Article

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: https://orcid.org/0000-0002-5847-7886, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:10.1016/j.tet.2012.08.062)

Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)

Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.01.081)

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)

Puglisi, Antonino, Spencer, John, Oliveri, Valentina, Vecchio, Graziella, Kong, Xiaole, Clarke, James and Milton, John (2011) Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(iii) complexes. Dalton Transactions, 41 (10). pp. 2877-2883. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/c1dt11677k)

Puglisi, Antonino, Spencer, John, Clark, James and Milton, John (2011) Microwave-assisted synthesis of 6-amino-β-cyclodextrins. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 73 (1-4). pp. 475-478. ISSN 0923-0750 (Print), 1573-1111 (Online) (doi:10.1007/s10847-011-0054-z)

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)

Spencer, John, Nielsen, Birthe ORCID: https://orcid.org/0000-0002-0849-4987, Thomas, Michael J.K., Male, Louise and Coles, Simon J. (2011) The Knoevenagel product of indolin-2-one and ferrocene-1,1′-dicarbaldehyde. Acta Crystallographica Section C, 67 (7). m245-m248. ISSN 0108-2701 (doi:10.1107/S0108270111021536)

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)

Spencer, John, Baltus, Christine B., Press, Neil J., Harrington, Ross W. and Clegg, William (2011) Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings. Tetrahedron Letters, 52 (31). pp. 3963-3968. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.05.025)

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875 (doi:10.1021.ml100295v)

Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (Print), 1520-6041 (Online) (doi:10.1021/om200278j)

Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:10.1016/j.bmc.2011.01.010)

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.07.147)

Callear, Samantha K., Spencer, John, Patel, Hiren, Deadman, John J. and Hursthouse, Michael B. (2010) Crystal structures of two palladacycles from the C-H activation of 2-(Thiophen-2-yl)pyridine. Journal of Chemical Crystallography, 41 (4). pp. 523-527. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-010-9913-5)

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:10.1021/co100011g)

Spencer, John, Rathnam, Rajendra P. and Chowdhry, Babur Z. (2010) 1,4-Benzodiazipine-2-ones in medicinal chemistry. Future Medicinal Chemistry, 2 (9). pp. 1441-1449. ISSN 1756-8919 (doi:10.4155/fmc.10.226)

Spencer, John (2010) Microwave chemistry enabling the synthesis of biologically relevant amines. Future Medicinal Chemistry, 2 (2). pp. 161-168. ISSN 1756-8919 (Print), 1756-8927 (Online) (doi:10.4155/fmc.09.114)

Spencer, John (2010) Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines. Future Medicinal Chemistry, 2 (2). pp. 161-168. ISSN 1756-8919 (Print), 1756-8927 (Online) (doi:10.4155/fmc.09.114)

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:10.1107/S0108270109054134)

Spencer, John (2010) Welcome to 'microwaves in medicinal chemistry'. Future Medicinal Chemistry, 2 (2). p. 149. (doi:10.4155/fmc.09.169)

Spencer, John (2010) Conference report: 7th Annual Congress of International Drug Discovery Science and Technology. Future Medicinal Chemistry, 2 (1). pp. 21-23. ISSN 1756-8919 (doi:10.4155/FMC.09.151)

Spencer, John, Rathnam, Rajendra P. and Chowdhry, Babur Z. (2010) Methodology issues and design approach of VLE on mathematical concepts acquisition within secondary education in England. Future Medicinal Chemistry, 2 (9). pp. 1441-1449. ISSN 1756-8919 (doi:10.4155/fmc.10.226)

Neto, Brenno A.D., Lapis, Alexandre A.M., Netz, Paulo A., Spencer, John, Dias, Silvio L.P., Tamborim, Silvia M., Basso, Luiz A., Santos, Diógenes S. and Dupont, Jairton (2010) Synthesis and enzymatic evaluation of the guanosine analogue 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG): insights into the phosphorolysis reaction mechanism based on the blueprint transition state: SN1 or SN2? Journal of the Brazilian Chemical Society, 21 (1). pp. 151-156. ISSN 0103-5053 (Print), 1678-4790 (Online) (doi:10.1590/S0103-50532010000100022)

Spencer, John, Casini, Angela, Zava, Olivier, Rathnam, Rajendra P., Velhanda, Santosh K., Pfeffer, Michel, Callear, Samantha K., Hursthouse, Michael B. and Dyson, Paul J. (2009) Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles. Dalton Transactions (48). pp. 10731-10735. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/b912096c)

Spencer, John, Rathnam, Rajendra P., Montukuri, Mahesh, Kotha, Arun K., Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649, Hazrati, Ali, Hartley, John A., Male, Louise and Hursthouse, Michael B. (2009) Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. Dalton Transactions (22). pp. 4299-4303. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/b819061e)

Spencer, John, Mendham, Andrew P., Kotha, Arun K., Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649, Hillard, Elizabeth A., Jaouen, Gérard, Male, Louise and Hursthouse, Michael B. (2008) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transactions, 2009 (6). pp. 918-921. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/B816249B)

Spencer, John, Rathnam, Rajendra, Patel, Hiren and Anjum, Nazira (2008) Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo(CO)(6) and DBU. Tetrahedron, 64 (44). pp. 10195-10200. ISSN 0040-4020 (doi:10.1016/j.tet.2008.08.036)

Spencer, John, Gaffen, John, Grifin, Eric, Harper, Elaine A., Linney, Ian D., McDonald, Iain M., Roberts, Sonia P., Shaxted, Mark E., Adatia, Trushar and Bashall, Alan (2008) Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template. Bioorganic & Medicinal Chemistry, 16 (6). pp. 2974-2983. ISSN 0968-0896 (doi:10.1016/j.bmc.2007.12.047)

Spencer, John, Chowdhry, Babur Z., Mallet, Anthony I., Rathnam, Rajendra P., Adatia, Trushar, Bashall, Alan and Rominger, Frank (2008) C-H activations on a 1H-1,4-benzodiazepin-2(3H)-one template. Tetrahedron, 64 (26). pp. 6082-6089. ISSN 0040-4020 (doi:10.1016/j.tet.2008.01.059)

Spencer, John, Anjum, Nazira, Patel, Hiren, Rathnam, Rajendra and Verma, Jason (2007) Molybdenum hexacarbonyl and DBU reduction of nitro compounds under microwave irradiation. Synlett, 2007 (16). pp. 2557-2558. ISSN 0936-5214 (doi:10.1055/s-2007-986628)

Leyva, Lida, Sirlin, Claude, Rubio, Laura, Franco, Cecilia, Le Lagadec, Ronan, Spencer, John, Bischoff, Pierre, Gaiddon, Christian, Loeffler, Jean-Philippe and Pfeffer, Michel (2007) Synthesis of cycloruthenated compounds as potential anticancer agents. European Journal of Inorganic Chemistry, 2007 (19). pp. 3055-3066. ISSN 1434-1948 (doi:10.1002/ejic.200601149)

McDonald, Iain M., Austin, Carol, Buck, Ildiko M., Dunstone, David J., Gaffen, John, Griffin, Eric, Harper, Elaine A., Hull, Robert A.D., Kalindjian, S. Barret, Linney, Ian D., Low, Caroline M.R., Patel, Dipa, Pether, Michael J., Raynor, Michelle, Roberts, Sonia P., Shaxted, Mark E., Spencer, John, Steel, Katherine I.M., Sykes, David A., Wright, Paul T. and Xun, Wei (2007) [Letter] Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists. Journal of Medicinal Chemistry, 50 (20). pp. 4789-4792. ISSN 0022-2623 (Print), 1520-4804 (Online) (doi:10.1021/jm0707626)

Book Section

Spencer, John (2009) Microwave technology applied to medicinal chemistry. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

Spencer, John (2009) Case study on Maraviroc, a CCR5 Antagonist for HIV treatment. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

Spencer, John (2009) Current metallodrugs in cancer. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, Web update. ISBN 9780199234479

Spencer, John (2009) Combinatorial and parallel synthesis. In: Patrick, Graham L., (ed.) An introduction to medicinal chemistry. Oxford University Press, Oxford, pp. 307-331. ISBN 9780199234479

Spencer, John (2008) C-H activations via palladacycles. In: Dupont, Jairton and Pfeffer, Michel, (eds.) Palladacycles. Wiley-VCH, Weinheim, pp. 109-121. ISBN 9783527317813 (Print) 9783527623211 (Online) (doi:10.1002/9783527623211.ch6)

Spencer, John (2008) Other uses of palladacycles in synthesis. In: Dupont, Jairton and Pfeffer, Michel, (eds.) Palladacycles. Wiley-VCH, Weinheim, pp. 227-238. ISBN 9783527317813 (Print) 9783527623211 (Online) (doi:10.1002/9783527623211.ch10)

Dupont, Jairton, Consorti, C. and Spencer, John (2007) Organometallic pincer-type complexes: recent applications in synthesis and catalysis. In: Morales-Morales, David and Jensen, Craig M., (eds.) The Chemistry of Pincer Compounds. Elsevier, Amsterdam, pp. 1-24. ISBN 9780444531384 (doi:10.1016/B978-044453138-4/50002-7)

Conference Proceedings

Cherry, A., Amin, B., Baltus, C., Spencer, J. and Antonijevic, M. ORCID: https://orcid.org/0000-0002-5847-7886 (2011) Thermal analysis of a polymorphic biphenyl structural motifs. In: Published Meeting Abstracts [AAPS]. The AAPS Journal, 2011 . American Association of Pharmaceutical Scientists (AAPS), Arlington, VA, USA. ISSN 1550-7416

Conference or Conference Paper

Owusu-Ware, Samuel K., Masud, Mohammed, Baltus, Christine, Spencer, John and Antonijevic, Milan ORCID: https://orcid.org/0000-0002-5847-7886 (2011) Thermal stability implication of positional isomerism of novel biphenyl derivatives. In: 2011 AAPS Annual Meeting and Exposition, 23-27 Oct 2011, Washington Convention Center, Washington, D.C., USA. (Unpublished)

Parbhu Patel, Asha, Deacon, Andrew D., Spencer, John, Raj, Rathnam, Harbige, Laurence and Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496 (2010) The benzodiazepine class of compounds as a potential for the treatment of cutaneous leishmaniasis. In: XII International Congress of Parasitology ICOPA, 15 - 20 Aug 2010, Melbourne, Australia. (Unpublished)