Ojo, Omorogieva ORCID: https://orcid.org/0000-0003-0071-3652, Onilude, Yemi ORCID: https://orcid.org/0000-0003-0070-7949, Ojo, Osarhumwese Osaretin, Apau, Victoria, Kazangarare, Ivy, Agyapong, David, Brooke, Joanne and Wang, Xiaohua (2026) Dietary polysaccharides and the regulation of blood glucose and lipid parameters: a narrative review. Nutrients, 18 (13):2143. ISSN 2072-6643 (Online) (doi:10.3390/nu18132143)

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Abstract

The increase in the prevalence of non-communicable diseases globally has been attributed in part to poor lifestyle choices, including unhealthy dietary habits. Dietary polysaccharides, including resistant starch and non-starch polysaccharides, have gained increasing attention due to their potential role in the regulation of glucose and lipid metabolism. Therefore, the aim of this review was to evaluate the role of dietary polysaccharides in the regulation of blood glucose and lipid parameters. Method: A narrative review approach was adopted for this review. Searches were conducted through EBSCOHost and involved the following databases: Medline, APA PsycInfo, CINAHL Plus with Full Text, Psychology and Behavioural Sciences collection, Academic Search Premier and APA PsycArticles. Searches were conducted on 14 April 2026 and covered all records available from database inception to the search date. Search terms were combined using Boolean operators (AND/OR). The reference list of articles was also searched for more articles. Results: Twenty-one studies from thirteen different countries were included in this review. Based on narrative synthesis, five themes were identified: the effects of dietary polysaccharides on glycaemia, insulin, lipids, energy intake and satiety/appetite. The findings demonstrated considerable heterogeneity across studies. While several studies reported improvements in fasting glucose, postprandial glucose, glycated haemoglobin and insulin responses following resistant starch and non-starch polysaccharide interventions, other studies found no significant effects on glycaemic control or insulin levels. Lipid outcomes were similarly inconsistent, although some studies reported reductions in total cholesterol and low density lipoprotein cholesterol. Effects on energy intake and satiety varied according to the type and physicochemical characteristics of the polysaccharide investigated. Conclusion: The findings of this review suggest that dietary polysaccharides may contribute to improvements in glucose control and lipid metabolism, although the magnitude and consistency of these effects vary across populations, intervention types and study designs. The most frequently reported beneficial findings related to blood glucose parameters, although substantial heterogeneity remained across studies. Further, well-designed studies, including randomised controlled trials with longer durations, are needed to fully establish the role of dietary polysaccharides in the control of blood glucose and lipid parameters.

Item Type:	Article
Additional Information:	This article belongs to the Special Issue Dietary Polysaccharides: Functional Properties and Health Implications.
Uncontrolled Keywords:	dietary polysaccharides, blood glucose, type 2 diabetes, lipids, satiety, gut microbiota
Subjects:	R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Chronic Illness and Ageing Faculty of Education, Health & Human Sciences > School of Health Sciences (HEA)
Related URLs:	https://doi.org/10.3390/nu18132143
Last Modified:	12 Aug 2026 07:55
URI:	https://gala.gre.ac.uk/id/eprint/54021

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