Junqueira, Laura Andrade ORCID: https://orcid.org/0000-0002-6461-2327, Tabriz, Atabak Ghanizadeh, Rousseau, Fiona, Raposo, Nádia Rezende Barbosa ORCID: https://orcid.org/0000-0001-5271-1048, Brandão, Marcos Antônio Fernandes and Douroumis, Dennis ORCID: https://orcid.org/0000-0002-3782-0091 (2022) Development of printable inks for 3D printing of personalized dosage forms: coupling of fused deposition modelling and jet dispensing. Journal of Drug Delivery Science and Technology, 80:104108. ISSN 1773-2247 (Print), 2588-8943 (Online) (doi:10.1016/j.jddst.2022.104108)

Preview

PDF (Open Access Article) 51942 DOUROUMIS_Development_Of_Printable_Inks_For_3D_Printing_Of_Personalized_Dosage_Forms_(OA)_2022.pdf - Published Version Available under License Creative Commons Attribution. Download (6MB) | Preview

Abstract

3D printing technologies have gained significant attention for the development of personalized pharmaceutical dosage forms. Here we present the coupling of Fused Deposition Modelling (FDM) and jet dispensing for the printing of polyvinyl alcohol (PVA) tablets followed by dispensing of rosuvastatin calcium (RSV) – polymer inks for customization of the drug dissolution rates. By using the drop on demand approach, methacrylate (EUDRAGIT EPO), vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64), and ethylcellulose (Aqualon) inks loaded with RSV were dispensed in FDM printed tablets, bearing 5 and 15 mg of active dose respectively. Physicochemical characterization revealed that RSV was molecularly dispersed in the deposited inks. Various dissolution rates were obtained based on the polymer solubility in the dissolution media and the drug loading. The study is a paradigm of printing personalized dosage forms through the development of suitable inks.

Item Type:	Article
Uncontrolled Keywords:	three-dimensional printing, personalization, fused deposition modelling, jet dispensing, solid dispersion, Rosuvastatin
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	12 Dec 2025 15:41
URI:	https://gala.gre.ac.uk/id/eprint/51942

Actions (login required)

View Item

Downloads