Nandi, Uttom ORCID: https://orcid.org/0000-0003-1777-3862, Onyesom, Ichioma and Douroumis, Dennis ORCID: https://orcid.org/0000-0002-3782-0091 (2021) Transferrin conjugated stealth liposomes for sirolimus active targeting in breast cancer. Journal of Drug Delivery Science and Technology, 66:102900. ISSN 1773-2247 (Print), 2588-8943 (Online) (doi:10.1016/j.jddst.2021.102900)

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Abstract

In the present work Stealth liposomes were conjugated with transferrin (Tf) for sirolimus (SRM) active targeting and the treatment of breast cancer. The developed Tf-Stealth liposomes were assessed for their particle size distribution, zeta potential and drug encapsulation. In vitro evaluation in BT-474 cancer cells demonstrated an antiproliferative effect of the sirolimus loaded Tf-DPPC-Stealth liposomes exhibiting greater cell cytotoxicity compared to Tf-DSPC-Stealth. Sirolimus loaded liposomes were injected intravenously and showed superior anticancer effect for Tf-Stealth nanoparticles with significant tumour growth suppression in comparison to the free drug and non-conjugated Stealth nanoparticles. The results reveal that sirolimus encapsulated Tf-Stealth liposomes are a potential drug delivery carrier for tumour active targeting and the treatment of breast cancer.

Item Type:	Article
Uncontrolled Keywords:	transferrin-conjugated liposomes, sirolimus drug delivery, breast cancer targeting, stealth nanoparticles, in vitro and in vivo evaluation
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	12 Dec 2025 15:51
URI:	https://gala.gre.ac.uk/id/eprint/51940

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