Akanda, Mushfiq, Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496 and Douroumis, Dennis ORCID: https://orcid.org/0000-0002-3782-0091 (2021) In vivo evaluation of nanostructured lipid carrier systems (NLCs) in mice bearing prostate cancer tumours. Drug Delivery and Translational Research, 13 (8). pp. 2083-2095. ISSN 2190-393X (Print), 2190-3948 (Online) (doi:10.1007/s13346-021-01095-1)

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Abstract

Nanostructure lipid carriers (NLCs) were developed for the delivery of curmumin (CRN), a potent anticancer agent with low bioavailability, for the treatment of prostate cancer. NLCs prepared using high pressure homogenization (HPH) with around 150 nm particle size, − 40 V ζ-potential and excellent long-term stability. Cellular uptake of CRN-SLN showed nanoparticle localization in the cytoplasm around the nucleus. CRN-NLCs were assessed using flow cytometry and found to cause early and late apoptotic events at 100 μg/ml CRN concentrations. CRN-NLC nanoparticles were administrated to nude mice with LNCaP prostate cancer xenografts and demonstrated substantial tumour volume suppression (40%) with no weight loss compared to pure CRN (ethanolic solution). Overall, NLCs were proved a suitable carrier for passive drug delivery and cancer treatment.

Item Type:	Article
Uncontrolled Keywords:	nanostructured lipid carriers (NLCs), curcumin drug delivery, prostate cancer treatment, apoptosis & cellular uptake, in vivo anticancer evaluation
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	12 Dec 2025 16:34
URI:	https://gala.gre.ac.uk/id/eprint/51939

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