Tabriz, Atabak Ghanizadeh, Nandi, Uttom, Scoutaris, Nicolaos, Sanfo, Karifa, Alexander, Bruce, Gong, Yuchuan, Hui, Ho-Wah, Kumar, Sumit and Douroumis, Dennis ORCID: https://orcid.org/0000-0002-3782-0091 (2022) Personalised paediatric chewable ibuprofen tablets fabricated using 3D micro-extrusion printing technology. International Journal of Pharmaceutics, 626:122135. ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:10.1016/j.ijpharm.2022.122135)

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Abstract

Three-dimensional (3D) printing is becoming an attractive technology for the design and development of personalized paediatric dosage forms with improved palatability. In this work micro-extrusion based printing was implemented for the fabrication of chewable paediatric ibuprofen (IBU) tablets by assessing a range of front runner polymers in taste masking. Due to the drug-polymer miscibility and the IBU plasticization effect, micro-extrusion was proved to be an ideal technology for processing the drug/polymer powder blends for the printing of paediatric dosage forms. The printed tablets presented high printing quality with reproducible layer thickness and a smooth surface. Due to the drug-polymer interactions induced during printing processing, IBU was found to form a glass solution confirmed by differential calorimetry (DSC) while H-bonding interactions were identified by confocal Raman mapping. IBU was also found to be uniformly distributed within the polymer matrices at molecular level. The tablet palatability was assessed by panellists and revealed excellent taste masking of the IBU’s bitter taste. Overall micro-extrusion demonstrated promising processing capabilities of powder blends for rapid printing and development of personalised dosage forms.

Item Type:	Article
Uncontrolled Keywords:	3D printing, personalized, paediatric, micro-extrusion, taste masking, Raman mapping
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	12 Dec 2025 16:16
URI:	https://gala.gre.ac.uk/id/eprint/51938

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