Paccoia, Federico, Tomarelli, Elena, Lam, Kevin ORCID: https://orcid.org/0000-0003-1481-9212 and Gioiello, Antimo (2025) Steroids under voltage: unlocking reactivity with electrochemistry. Trends in chemistry:00704. ISSN 2589-5974 (doi:10.1016/j.trechm.2025.09.015)

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Abstract

Steroids are ubiquitous natural compounds that play essential physiological roles in both plants and animals. Owing to their diverse biological activities, including anti-inflammatory, antitumor, antiviral, and antimicrobial effects, steroidal compounds have found widespread therapeutic uses in the treatment of numerous clinical conditions. Unsurprisingly, the global steroid market is valued at approximately US$4 billion. Despite their broad impact in chemical research and the pharmaceutical industry, the synthesis of steroids remains challenging due to the structural complexity and limited availability of efficient synthetic methodologies. This review highlights recent advances in electrochemically enabled approaches for steroid activation and functionalization, aiming to inspire innovative and sustainable strategies for steroid manipulation and production.

Item Type:	Article
Additional Information:	Declaration of interests A.G. is cofounder of Tes Pharma (www.tespharma.com). - MP
Uncontrolled Keywords:	chemical technologies, electrochemistry, late-stage functionalization, steroids
Subjects:	Q Science > Q Science (General) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	https://www.sciencedirect.com/science/ar...
Last Modified:	27 Oct 2025 10:49
URI:	https://gala.gre.ac.uk/id/eprint/51313

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