Totea, Ana-Maria ORCID: https://orcid.org/0000-0003-0974-7648, Dorin, Irina, Laity, Peter, Conway, Barbara ORCID: https://orcid.org/0000-0001-5570-3318, Waters, Laura ORCID: https://orcid.org/0000-0001-9172-0828 and Asare-Addo, Kofi ORCID: https://orcid.org/0000-0001-6824-5336 (2020) Use of thermodynamics in understanding drug release from xanthan gum matrices: the influence of clay-drug complexes. Carbohydrate Polymer Technologies and Applications, 1:100012. ISSN 2666-8939 (Online) (doi:10.1016/j.carpta.2020.100012)

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Abstract

The aim of this study was to outline a novel way of understanding the controlled drug release from drug-clay-polymer matrices using isothermal calorimetry (ITC) as a complementary technique to dissolution studies. ITC results showed that the binding phenomenon between the model drug propranolol hydrochloride (PPN) and magnesium aluminium silicate (MAS) in the presence of xanthan gum (XG was spontaneous and enthalpically driven (negative enthalpy (ΔH) and small entropy (-T∆S)). This may be due to the competition for PPN due to the anionic nature of XG. Dissolution results showed that when using the MAS-PPN complexes, 10 % w/w XG polymer level was enough to significantly reduce the burst release. When used together, ITC and dissolution studies may help a formulator understand and identify interactions which occur during dissolution studies and may be beneficial to the controlled drug delivery system.

Item Type:	Article
Additional Information:	Funding Information: Ana-Maria Totea and the authors thank the University of Huddersfield for funding. Publisher Copyright: © 2020.
Uncontrolled Keywords:	complexation, Isothermal titration calorimetry, Magnesium aluminium silicate, Propranolol hydrochloride, Xanthan gum
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	04 Mar 2026 10:00
URI:	https://gala.gre.ac.uk/id/eprint/51217

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