Association of lifestyle, dietary pattern, and liver function with cognition in older adults: findings from a cross-section
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Wang, Xixiang, Ren, Xiuwen, Liu, Yu, Liu, Lu, Xu, Jingjing, Zhou, Shaobo 
ORCID: https://orcid.org/0000-0001-5214-2973, Wang, Ying and Yuan, Linhong
(2025)
Association of lifestyle, dietary pattern, and liver function with cognition in older adults: findings from a cross-section.
Frontiers in Nutrition, 12.
ISSN 2296-861X (Online)
(In Press)
(doi:10.3389/fnut.2025.1655601)
Abstract
Background: Individual lifestyle factors, dietary patterns, and liver function are each associated with cognitive ability, but their combined influence on cognition remains unclear. This study investigated the effects of lifestyle, dietary patterns, and liver function on cognitive impairment in older adults.
Methods: We recruited 1,096 community-dwelling older adults; 630 completed cognitive testing. Lifestyle and diet were assessed using a Healthy Lifestyle Score (HLS) and a Healthy Dietary Score (HDS). Liver function was evaluated with four predictive indicators: AST/HDL-C, ALT/HDL-C, HSI, and ZJU. Cognitive function was measured with the Montreal Cognitive Assessment (MoCA). Logistic regression, receiver operating characteristic (ROC) curves, and restricted cubic splines (RCS) were used to examine associations.
Results: HLS was negatively correlated with liver function indicators (r_AST/HDL-C = −0.156; r_ZJU = −0.270; both P < 0.001), while HDS was positively correlated with MoCA scores (r = 0.074; P < 0.05). Poor liver function—reflected by higher plasma AST/HDL-C—was associated with increased risk of mild cognitive impairment (MCI) (OR = 1.029; P = 0.007). ROC analysis showed AST/HDL-C had the greatest predictive power for MCI (AUC = 0.634). RCS analysis indicated positive, nonlinear associations of AST/HDL-C and ALT/HDL-C with MCI risk, with cut-offs of 14.1 and 10.1, respectively.
Conclusions: Impaired liver function is strongly associated with cognitive impairment, underscoring the importance of maintaining liver health to prevent MCI in the elderly. A healthier lifestyle correlated with better liver and cognitive function, and a balanced diet was associated with improved cognitive outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | lifestyle, dietary pattern, Liver function, Mild Cognitive Impairment, AST/HDL-C |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Faculty / School / Research Centre / Research Group: | Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI) |
| Related URLs: | |
| Last Modified: | 25 Sep 2025 10:06 |
| URI: | https://gala.gre.ac.uk/id/eprint/51076 |
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