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Investigation of the interaction between poloxamer 407 and poly (ethylene glycol) 600

Investigation of the interaction between poloxamer 407 and poly (ethylene glycol) 600

Kianfar, F., Chowdhry, B.Z., Boateng, J.S. ORCID: 0000-0002-6310-729X and Antonijevic, M.D. ORCID: 0000-0002-5847-7886 (2010) Investigation of the interaction between poloxamer 407 and poly (ethylene glycol) 600. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1341-1342. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/j.2042-7158.2010.01178.x)

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Abstract

The aim of this study was to evaluate the interactions between poly (ethylene glycol) (PEG) 600 and poloxamer 407 prior to their use in a pharmaceutical formulation.
Chemical interactions between various ingredients alter the stability of pharmaceutical product [1]. Investigating the interaction between starting materials is a pre-requisite to develop a stable high quality pharmaceutical formulation. Changes in melting point [2] directly influence the stability of a product. One of the fundamental changes that might modify the melting point of a compound and consequently alter the stability of the system is the interaction between excipient(s) and API(s). The formation of a mixture following the interaction between component compounds, influences the characteristics of the system which therefore need to be determined.

Item Type: Article
Additional Information: [1] Abstract published in Journal of Pharmacy and Pharmacology, Volume 62, Issue 10, October 2010 - Special Issue: UK-PharmSci 2010 - The Science of Medicines. Abstracts from the UK conference, 1-3 September 2010.
Uncontrolled Keywords: PEG600, poloxamer 407, chemical interactions, differential scanning calorimetry
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Life & Sports Sciences
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4424

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