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Leishmania and its host cell: a complex relationship

Leishmania and its host cell: a complex relationship

Cheke, R. ORCID: 0000-0002-7437-1934, Getti, G. T. ORCID: 0000-0003-1402-8496, Poole, P., George, J. and Humber, D. P. (2006) Leishmania and its host cell: a complex relationship. ICOPA XI: proceedings of the 11th International Congress of Parasitology. Medimond SRL, Bologna, Italy, pp. 397-401. ISBN 8875872724

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Leishmania parasites invade host macrophages, causing infections that are either limited to skin (cutaneous), or spread" to internal organs (visceral). Macrophage-parasite interactions were investigated for three Leishmania species responsible for cutaneous leishmaniasis: L. major, L. aethiopica and L. tropica, using a monocyte cell line (THP-l). Fluorescence 2-D Difference Gel Electrophoresis (DIGE) was used and proteins differentially expressed during
infection were identified. Over 100 proteins showed significant changes of expression following infection with each of the three species tested. Proteins of interest were then separated, digested with trypsin and the peptide masses measured using MALDI-TOF. The identities of the proteins were elucidated by PMF. The identities and the involvement of the DE proteins will be discussed.

Item Type: Book Section
Additional Information: This forms part of a published proceedings from 11th International Congress of Parasitology (ICOPA XI), held 6-11 August 2006, Glasgow, Scotland.
Uncontrolled Keywords: Leishmania
Subjects: Q Science > Q Science (General)
Q Science > QL Zoology
Q Science > QR Microbiology
Faculty / Department / Research Group: Faculty of Education, Health & Human Sciences > Department of Life & Sports Sciences
Faculty of Engineering & Science > Natural Resources Institute
Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
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Last Modified: 29 Jan 2020 13:44
Selected for GREAT 2016: None
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