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Dietary Fibre, Gut Microbiota Dysbiosis and Type 2 Diabetes

Dietary Fibre, Gut Microbiota Dysbiosis and Type 2 Diabetes

Ojo, Omorogieva ORCID: 0000-0003-0071-3652, Feng, Qianqian, Ojo, Osarhumwese Osaretin and Wang, Xiaohua (2020) Dietary Fibre, Gut Microbiota Dysbiosis and Type 2 Diabetes. In: The 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease. Special Issue . MDPI, Basel, Switzerland, pp. 1-4. ISSN 2072-6643 (In Press) (doi:https://doi.org/10.3390/IECN2020-06986)

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Abstract

Background:
Diabetes prevalence is on the increase globally and its impact on those with the condition in terms of acute and chronic complications can be profound. People with type 2 diabetes constitute the majority of those with diabetes and the risk factors include obesity, lifestyle and gut microbiota dysbiosis. Poor dietary intake has been reported to influence the community of gut microbiome. Therefore, higher intake of dietary fibre may alter the environment in the gut and promote microbial growth and proliferation.

Aim:
This is a systematic review and meta-analysis which examined the effect of dietary fibre on gut microbiota in patients with type 2 diabetes. Method: This review was conducted in line with the PRISMA framework. Databases were searched for relevant articles which were screened based on inclusion and exclusion criteria. Results: Nine articles which met the inclusion criteria were selected for the systematic review and meta-analysis. High dietary intake significantly improved (p < 0.05) the abundance of Bifidobacterium, total SCFAs and HbA1c.

Discussion:
The promotion of SCFA producers in greater diversity and abundance by dietary fibre may have resulted in improvement in glycated haemoglobin, partly due to increased GLP–1 production. Conclusion: Consumption of high dietary fibre has significant (p < 0.05) effect on Bifidobacterium, total SCFAs and HbA1c, but not (p > 0.05) on propionic, butyric, and acetic acid, fasting blood glucose and HOMAR–IR.

Item Type: Conference Proceedings
Title of Proceedings: The 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease
Additional Information: © 2020 by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords: type 2 diabetes; dietary fibre; gut microbiota; dysbiosis; short chain fatty acids; glycated haemoglobin; fasting blood glucose; adverse events
Faculty / Department / Research Group: Faculty of Education, Health & Human Sciences
Faculty of Education, Health & Human Sciences > Department of Adult Nursing & Paramedic Science
Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development
Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Chronic Illness and Ageing
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Last Modified: 02 Nov 2020 21:16
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/30056

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