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Frontostriatal activity and connectivity increase during proactive inhibition across adolescence and early adulthood

Frontostriatal activity and connectivity increase during proactive inhibition across adolescence and early adulthood

Vink, Matthijs, Zandbelt, Bram B., Gladwin, Thomas, Hillegers, Manon, Hoogendam, Janna Marie, van den Wildenberg, Wery P.M., Du Plessis, Stefan and Kahn, René S. (2014) Frontostriatal activity and connectivity increase during proactive inhibition across adolescence and early adulthood. Human Brain Mapping, 35 (9). pp. 4415-4427. ISSN 1065-9471 (Print), 1097-0193 (Online) (doi:https://doi.org/10.1002/hbm.22483)

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Abstract

During adolescence, functional and structural changes in the brain facilitate the transition from childhood to adulthood. Because the cortex and the striatum mature at different rates, temporary imbalances in the frontostriatal network occur. Here, we investigate the development of the subcortical and cortical components of the frontostriatal network from early adolescence to early adulthood in 60 subjects in a cross-sectional design, using functional MRI and a stop-signal task measuring two forms of inhibitory control: reactive inhibition (outright stopping) and proactive inhibition (anticipation of stopping). During development, reactive inhibition improved: older subjects were faster in reactive inhibition. In the brain, this was paralleled by an increase in motor cortex suppression. The level of proactive inhibition increased, with older subjects slowing down responding more than younger subjects when anticipating a stop-signal. Activation increased in the right striatum, right ventral and dorsal inferior frontal gyrus, and supplementary motor area. Moreover, functional connectivity during proactive inhibition increased between striatum and frontal regions with age. In conclusion, we demonstrate that developmental improvements in proactive inhibition are paralleled by increases in activation and functional connectivity of the frontostriatal network. These data serve as a stepping stone to investigate abnormal development of the frontostriatal network in disorders such as schizophrenia and attention-deficit hyperactivity disorder.

Item Type: Article
Uncontrolled Keywords: adolescence, cognitive control, connectivity, development, frontostriatal network, response inhibition
Subjects: Q Science > Q Science (General)
Faculty / Department / Research Group: Faculty of Education, Health & Human Sciences
Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development
Last Modified: 21 Apr 2020 13:15
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: REF 2
URI: http://gala.gre.ac.uk/id/eprint/27690

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