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Resveratrol: A potential hippocampal plasticity enhancer

Resveratrol: A potential hippocampal plasticity enhancer

Pereira Dias, Gisele ORCID: 0000-0001-7276-2010, Cocks, Graham, Bevilaqua, Mário Cesar do Nascimento, Nardi, Antonio Egidio and Thuret, Sandrine (2016) Resveratrol: A potential hippocampal plasticity enhancer. Oxidative Medicine and Cellular Longevity, 2016:9651236. ISSN 1942-0900 (Print), 1942-0994 (Online) (doi:

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The search for molecules capable of restoring altered hippocampal plasticity in psychiatric and neurological conditions is one of the most important tasks of modern neuroscience. It is well established that neural plasticity, such as the ability of the postnatal hippocampus to continuously generate newly functional neurons throughout life, a process called adult hippocampal neurogenesis (AHN), can be modulated not only by pharmacological agents, physical exercise, and environmental enrichment, but also by “nutraceutical” agents. In this review we focus on resveratrol, a phenol and phytoalexin found in the skin of grapes and red berries, as well as in nuts. Resveratrol has been reported to have antioxidant and antitumor properties, but its effects as a neural plasticity inducer are still debated. The current review examines recent evidence implicating resveratrol in regulating hippocampal neural plasticity and in mitigating the effects of various disorders and diseases on this important brain structure. Overall, findings show that resveratrol can improve cognition and mood and enhance hippocampal plasticity and AHN; however, some studies report opposite effects, with resveratrol inhibiting aspects of AHN. Therefore, further investigation is needed to resolve these controversies before resveratrol can be established as a safe coadjuvant in preventing and treating neuropsychiatric conditions.

Item Type: Article
Additional Information: Copyright © 2016 Gisele Pereira Dias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: resveratrol, hippocampal plasticity, adult hippocampal neurogenesis
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Faculty / School / Research Centre / Research Group: Faculty of Education, Health & Human Sciences
Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified: 29 Jun 2019 08:01

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