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Survival time and differences between dementia with Lewy bodies and Alzheimer’s disease following diagnosis: A meta-analysis of longitudinal studies

Survival time and differences between dementia with Lewy bodies and Alzheimer’s disease following diagnosis: A meta-analysis of longitudinal studies

Mueller, Christoph, Soysal, Pinar, Rongve, Arvid, Turan Isik, Ahmet, Thompson, Trevor ORCID: 0000-0001-9880-782X, Maggi, Stefania, Smith, Lee, Basso, Cristina, Stewart, Robert, Ballard, Clive, O’Brien, John T., Aarsland, Dag, Stubbs, Brendon and Veronese, Nicola (2019) Survival time and differences between dementia with Lewy bodies and Alzheimer’s disease following diagnosis: A meta-analysis of longitudinal studies. Ageing Research Reviews, 50. pp. 72-80. ISSN 1568-1637 (Print), 1872-9649 (Online) (doi:https://doi.org/10.1016/j.arr.2019.01.005)

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Abstract

Objective:
To synthesize the evidence across longitudinal studies comparing survival in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD).

Methods:
We conducted a systematic review and meta-analysis of studies comparing survival in clinically diagnosed DLB to AD. Longitudinal cohort studies were identified through a systematic search of major electronic databases from inception to May 2018. A random effects meta-analysis was performed to calculate survival time and relative risk of death.

Results:
Overall, 11 studies were identified including 22,952 patients with dementia: 2,029 with DLB (mean diagnosis age 76.3; 47% female) compared with 20,923 with AD (mean diagnosis age 77.2; 65.1% female). Average survival time in DLB from diagnosis was 4.11 years (SD ±4.10) and in AD 5.66 (SD ±5.32) years, equating to a 1.60 (95% CI: -2.44 to -0.77) years shorter in DLB (p<0.01). Relative risk of death was increased by 1.35 (95%CI: 1.17-1.55) in DLB compared to AD (p<0.01). Differences in survival were not explained by follow-up time, age at diagnosis, gender, or cognitive score.

Conclusions:
There is consistent evidence for higher and earlier mortality in DLB compared to AD. This is important for all stakeholders and underlines the importance of expanding research into DLB.

Item Type: Article
Uncontrolled Keywords: Dementia; Lewy bodies; Alzheimer’s disease; mortality
Faculty / Department / Research Group: Faculty of Education & Health
Faculty of Education & Health > Applied Psychology Research Group
Faculty of Education & Health > Department of Psychology, Social Work & Counselling
Last Modified: 24 Jan 2019 13:08
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/22530

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