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An investigation into the flowability of fine powders used in pharmaceutical industries

An investigation into the flowability of fine powders used in pharmaceutical industries

Garg, Vivek, Mallick, S. S., García-Trinanes, Pablo ORCID: 0000-0002-4993-2250 and Berry, Robert James (2018) An investigation into the flowability of fine powders used in pharmaceutical industries. Powder Technology, 336. pp. 375-382. ISSN 0032-5910 (Print), 1873-328X (Online) (doi:https://doi.org/10.1016/j.powtec.2018.06.014)

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Abstract

This paper investigates into the flow properties of two popular pharmaceutical excipients (Calcium sulphate and Dicalcium phosphate) and their respective feeder hopper design requirements. There are numerous problems related to poor powder flowability that are faced by pharmaceutical industries, due to a lack of fundamental understanding of powder flow properties and their effects on hopper design parameters (Standard, 2008 [1]). Characterization tests confirmed that the Dicalcium phosphate powder displayed a smaller particle size, larger specific surface area and higher value of Hausner ratio compared to Calcium sulphate powder indicating that Dicalcium phosphate powders are markedly more cohesive. This was validated by the instantaneous and time consolidation flow function curves which showed that the Dicalcium phosphate was the more cohesive. Powder flow function and wall friction tests were carried out on a ring type shear tester working on the basis of Jenike's principle. Based on the instantaneous test results, Dicalcium phosphate was found to require a larger hopper outlet dimension for the same hopper half angle compared to Calcium sulphate. The time consolidation test results have shown that both Dicalcium phosphate and Calcium sulphate gained strength during static storage and have become more cohesive. A simple empirical model for powder cohesion and unconfined yield stress has been developed and validated with a number of experimental values derived from common pharmaceutical powders.

Item Type: Article
Uncontrolled Keywords: Flow property testing; Pharmaceutical excipients; Flow function; Time consolidation; Hopper design
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Applied Engineering & Management
Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Last Modified: 19 Jul 2018 16:30
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/20414

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