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Mineralized alginate hydrogels using marine carbonates for bone tissue engineering applications

Mineralized alginate hydrogels using marine carbonates for bone tissue engineering applications

Diaz-Rodriguez, P., García-Triñanes, P. ORCID: 0000-0002-4993-2250, Echezarreta-López, M. M., Santoveña, A. and Landin, M. (2018) Mineralized alginate hydrogels using marine carbonates for bone tissue engineering applications. Carbohydrate Polymers, 195. pp. 235-242. ISSN 0144-8617 (Print), 1879-1344 (Online) (doi:https://doi.org/10.1016/j.carbpol.2018.04.101)

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Abstract

The search for an ideal bone tissue replacement has led to the development of new composite materials designed to simulate the complex inorganic/organic structure of bone. The present work is focused on the development of mineralized calcium alginate hydrogels by the addition of marine derived calcium carbonate biomineral particles. Following a novel approach, we were able to obtain calcium carbonate particles of high purity and complex micro and nanostructure dependent on the source material. Three different types of alginates were selected to develop inorganic/organic scaffolds in order to correlate alginate composition with scaffold properties and cell behavior. The incorporation of calcium carbonates into alginate networks was able to promote extracellular matrix mineralization and osteoblastic differentiation of mesenchymal stem cells when added at 7 mg/ml. We demonstrated that the selection of the alginate type and calcium carbonate origin is crucial to obtain adequate systems for bone tissue engineering as they modulate the mechanical properties and cell differentiation.

Item Type: Article
Uncontrolled Keywords: biominerals; mineralization; bone; hydrogel; marine carbonate particles; tissue engineering
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Applied Engineering & Management
Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Last Modified: 19 Jun 2019 14:20
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: GREAT a
Selected for GREAT 2019: GREAT 6
URI: http://gala.gre.ac.uk/id/eprint/20108

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