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Characterization of chitin–metal silicates as binding superdisintegrants

Characterization of chitin–metal silicates as binding superdisintegrants

Rashid, Iyad, Daraghmeh, Nidal, Al-Remawi, Mayyas, Leharne, Stephen A., Chowdhry, Babur Z. and Badwan, Adnan (2009) Characterization of chitin–metal silicates as binding superdisintegrants. Journal of Pharmaceutical Sciences, 98 (12). pp. 4887-4901. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:https://doi.org/10.1002/jps.21781)

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Abstract

When chitin is used in pharmaceutical formulations, processing of chitin with metal silicates is advantageous, from both an industrial and pharmaceutical perspective, compared to processing using silicon dioxide. Unlike the use of acidic and basic reagents for the industrial preparation of chitin-silica particles, coprecipitation of metal silicates is dependent upon a simple replacement reaction between sodium silicate and metal chlorides. When coprecipitated onto chitin particles, aluminum, magnesium, or calcium silicates result in nonhygroscopic, highly compactable/disintegrable compacts. Disintegration and hardness parameters for coprocessed chitin compacts were investigated and found to be independent of the particle size. Capillary action appears to be the major contributor to both water uptake and the driving force for disintegration of compacts. The good compaction and compression properties shown by the chitin-metal silicates were found to be strongly dependent upon the type of metal silicate coprecipitated onto chitin. In addition, the inherent binding and disintegration abilities of chitin-metal silicates are useful in pharmaceutical applications when poorly compressible and/or highly nonpolar drugs need to be formulated. (C) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:4887-4901, 2009.

Item Type: Article
Additional Information: [1] First published online: 18 August 2009. [2] Issue published online: 22 OCT 2009. [3] Published as: Journal of Pharmaceutical Sciences, (2009) Volume 98, Issue 12, pp. 4887–4901. [4] The Journal of Pharmaceutical Sciences is published on behalf of the American Pharmacists Association.
Uncontrolled Keywords: chitin, metal silicates, coprecipitation, disintegrants, binders
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 05 Dec 2016 14:45
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/1596

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