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Evaluation of the accuracy of capillary hydroxybutyrate measurement compared with other measurements in the diagnosis of diabetic ketoacidosis: A systematic review.

Evaluation of the accuracy of capillary hydroxybutyrate measurement compared with other measurements in the diagnosis of diabetic ketoacidosis: A systematic review.

Ojo, Omorogieva ORCID: 0000-0003-0071-3652, Brooke, Joanne and Stiell, Marlon (2016) Evaluation of the accuracy of capillary hydroxybutyrate measurement compared with other measurements in the diagnosis of diabetic ketoacidosis: A systematic review. International Journal of Environmental Research and Public Health, 13 (9):837. pp. 1-9. ISSN 1660-4601 (Print), 1660-4601 (Online) (doi:https://doi.org/10.3390/ijerph13090837)

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Abstract

A complication of diabetes is diabetic ketoacidosis (DKA), which if left untreated is a life threatening condition. Prompt and accurate diagnosis of DKA is required for the commencement of life saving interventions. Measurements of ketone bodies in DKA have usually been through nitroprusside urine acetoacetate testing. The aim of this systematic review was to examine whether capillary β-hydroxybutyrate (β-OHB) testing is more accurate compared to other diagnostic methods of DKA. The following electronic databases were searched: EBSCO Host, MEDLINE, PSYCHInfo, CINAHL and Science Direct for publications from 1 January 2005 and up to and including 1 January 2016. Inclusion criteria were: Adults 18 years and over and known type 1 or type 2 diabetes. Retrospective and prospective observation studies were included. A total of nine studies met the inclusion criteria. Capillary β-OHB was found to have high sensitivity, specificity, positive predictive value and negative predictive value in identifying DKA compared to urinary ketone testing

Item Type: Article
Additional Information: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution.
Uncontrolled Keywords: Diabetes ketoacidosis; Type 1 diabetes; Type 2 diabetes; Emergency department; Point of care testing; Ketones
Faculty / Department / Research Group: Faculty of Education & Health
Faculty of Education & Health > Department of Adult Nursing & Paramedic Science
Faculty of Education & Health > Health & Society Research Group
Last Modified: 31 Jan 2018 10:44
Selected for GREAT 2016: None
Selected for GREAT 2017: GREAT b
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/15939

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