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A pilot study on the association between double positive Chlamydia pneumoniae serology and serum lipid indices alterations in obese adult females

A pilot study on the association between double positive Chlamydia pneumoniae serology and serum lipid indices alterations in obese adult females

Jaworowska, Agnieszka and Bazylak, Grzegorz (2011) A pilot study on the association between double positive Chlamydia pneumoniae serology and serum lipid indices alterations in obese adult females. Life Sciences, 89 (23-24). pp. 854-861. ISSN 0024-3205 (Print), 1879-0631 (Online) (doi:https://doi.org/10.1016/j.lfs.2011.09.013)

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Abstract

Aims: To study the relationship between Chlamydia pneumoniae serologic status and serum lipid abnormalities in apparently healthy obese female subjects living in urban areas.

Main methods: Serum samples from 117 apparently healthy females (mean age 50 years), classified as overweight/obese (OW/OB,n = 74) or normal weight (NW,n = 43) according to their body mass index (BMI), were tested for specific IgG and IgA antibodies against C. pneumoniae using ELISA assay. Serum triglycerides (TG), total cholesterol (TChol) and high-density lipoprotein cholesterol (HDLChol) concentrations were measured using enzymatic methods. Serum low-density lipoprotein cholesterol (LDLChol) was calculated using the Friedewald formula. Lifestyle data for all subjects were collected using a validated self-reported questionnaire.

Key findings: The prevalence of C. pneumoniae infection, as indicated by single positive serology (IgG+ or IgA+), was significantly higher among the OW/OB females than the NW subjects (38.5%vs.27.0%,p = 0.021). Females with double-positive serology (IgG+/IgA+) in the OW/OB group indicated significantly higher (p < 0.05) mean serum TG, TChol and LDLChol levels compared to the double seronegatives (IgG-/IgA-) from this group. On the contrary, no statistical differences (p > 0.05) were observed in these serum lipid indices between subjects in the NW group with considered opposite C. pneumoniae serology. Multivariate regression analysis on the 42 double-seropositive subjects, including both OW/OB and NW females and adjusted for such potential confounders as age, BMI and lifestyle factors, showed a significant association of double-positive C. pneumoniae serology with serum TG (β = 0.244;p = 0.049),LDLChol (β = 0.332;p = 0.037) and TChol-to-HDLChol ratio (β = 0.313;p = 0.042).

Significance: These results suggest that possible chronic C. pneumoniae infection is a potential non-dietary factor in modification of the serum lipid profile in the adult OW/OB females.

Item Type: Article
Uncontrolled Keywords: Obesity; C. pneumoniae; Serology; Respiratory tract infections; Chronic inflammation; Immune dysfunction
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 17 Oct 2016 09:13
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/14240

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