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Metabolic syndrome and lung function in schizophrenia: a pilot study

Metabolic syndrome and lung function in schizophrenia: a pilot study

Vancampfort, Davy, Probst, Michel, Stubbs, Brendon, Soundy, Andrew, De Herdt, Amber and De Hert, Marc (2014) Metabolic syndrome and lung function in schizophrenia: a pilot study. Psychiatry Research, 220 (1-2). pp. 58-62. ISSN 0165-1781 (doi:

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This pilot study aimed to explore relationships between metabolic and lung functions in patients with schizophrenia. Eighty patients with schizophrenia (55♂; 36.8±10.0 years) underwent a spirometry, were screened for metabolic syndrome (MetS), performed a 6-minute walk test (6MWT), and completed the International Physical Activity Questionnaire and the Psychosis evaluation tool for common use by caregivers. Patients with MetS (according to the International Diabetes Federation criteria) (n=28; 35%) had a reduced predicted forced expiratory volume for 1 second (77.4±13.2 versus 87.3±12.1%) and predicted forced vital capacity (75.3±11.1 versus 85.4±11.4%). Significantly more patients with MetS were diagnosed with restrictive lung dysfunction (RLD) (according to the Global Initiative for Chronic Obstructive Lung Disease criteria) (13 versus 8). Schizophrenia patients with RLD (n=21; 26.2%) had a significantly larger waist circumference (90.7±12.5 versus, 105.6±14.7 cm), were less physically active (653.6±777.9 versus 1517.9±1248.7 metabolic equivalent-min/week) and walked less on the 6MWT (502.6±92.3 versus 612.4±101.2 m) than patients without RLD. The present data suggest that in patients with schizophrenia RLD might be associated with metabolic dysfunctions. Further prospective analyses are required to elucidate the complex interrelationships between lung and metabolic functions in patients with schizophrenia.

Item Type: Article
Additional Information: [1] Received: November 13, 2013. Received in revised form: February 17, 2014. Accepted: June 5, 2014. Published online: June 12, 2014 - In Press, Accepted Manuscript. [2] Cite this article as: Davy Vancampfort, Michel Probst, Brendon Stubbs, Andrew Soundy, Amber De Herdt, Marc De Hert, Metabolic syndrome and lung function in schizophrenia: A pilot study, Psychiatry Research, [3] Publisher's note (Accepted Author's Manuscript version): This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. [4] Acknowledgement (funding): Davy Vancampfort is granted by the Research Foundation – Flanders (FWO–Vlaanderen) (Grant no. O6260).
Uncontrolled Keywords: spirometry, metabolic syndrome, physical activity, exercise, physical fitness, psychosis
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group: Faculty of Education, Health & Human Sciences
Last Modified: 19 Sep 2019 10:05

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