Ayensu, Isaac, Mitchell, John C. ORCID: 0000-0003-2945-3292 and Boateng, Joshua S. ORCID: 0000-0002-6310-729X (2012) In vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins. Carbohydrate Polymers, 89 (3). pp. 935-941. ISSN 0144-8617 (doi:https://doi.org/10.1016/j.carbpol.2012.04.039)

Full text not available from this repository.

Abstract

Chitosan and thiolated-chitosan based xerogels have been prepared by lyophilising aqueous gels of the polymers incorporating glycerol, d-mannitol and BSA with an annealing process. Analytical characterisation was by circular dichroism, infrared spectroscopy, X-ray diffraction and scanning electron microscopy. Swelling capacities of 1110 ± 23.3% and 480 ± 18.2% were obtained for the chitosan and TG-chitosan xerogels respectively. Thiolation caused improved in vitro mucoadhesive properties by demonstrating peak adhesive force of 4.5 ± 0.7 and 5.8 ± 0.2 N, and total work of adhesion of 6.5 ± 1.0 and 19 ± 0.8 mJ for chitosan and thiolated-chitosan xerogels respectively. In vitro drug dissolution studies using Bradford's assay showed BSA release of 91.5 ± 3.7% and 94.4 ± 7.3% from the chitosan and thiolated-chitosan xerogels respectively. These results demonstrate the potential of developing lyophilised thiolated-chitosan xerogels with optimised mucoadhesion characteristics for buccal mucosa delivery of proteinbased drugs.

Item Type:	Article
Uncontrolled Keywords:	thiolated-chitosan, lyophilisation, mucoadhesion, buccal delivery, protein
Subjects:	Q Science > QD Chemistry R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation
Last Modified:	17 Oct 2016 09:11
URI:	http://gala.gre.ac.uk/id/eprint/8235

Actions (login required)

View Item